Hosgood H Dean, Klugman Madelyn, Matsuo Keitaro, White Alexandra J, Sadakane Atsuko, Shu Xiao-Ou, Lopez-Ridaura Ruy, Shin Aesun, Tsuji Ichiro, Malekzadeh Reza, Noisel Nolwenn, Bhatti Parveen, Yang Gong, Saito Eiko, Rahman Shafiur, Hu Wei, Bassig Bryan, Downward George, Vermeulen Roel, Xue Xiaonan, Rohan Thomas, Abe Sarah K, Broët Philippe, Grant Eric J, Dummer Trevor J B, Rothman Nat, Inoue Manami, Lajous Martin, Yoo Keun-Young, Ito Hidemi, Sandler Dale P, Ashan Habib, Zheng Wei, Boffetta Paolo, Lan Qing
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, United States.
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; Nagoya, 464-8681, Japan.
Atmosphere (Basel). 2019 Jul;10(7). doi: 10.3390/atmos10070422. Epub 2019 Jul 23.
Household air pollution (HAP) is of public health concern with ~3 billion people worldwide (including >15 million in the US) exposed. HAP from coal use is a human lung carcinogen, yet the epidemiological evidence on carcinogenicity of HAP from biomass use, primarily wood, is not conclusive. To robustly assess biomass's carcinogenic potential, prospective studies of individuals experiencing a variety of HAP exposures are needed. We have built a global consortium of 13 prospective cohorts (HAPCO: Household Air Pollution Consortium) that have site- and disease-specific mortality and solid fuel use data, for a combined sample size of 587,257 participants and 57,483 deaths. HAPCO provides a novel opportunity to assess the association of HAP with lung cancer death while controlling for important confounders such as tobacco and outdoor air pollution exposures. HAPCO is also uniquely positioned to determine the risks associated with cancers other than lung as well as non-malignant respiratory and cardiometabolic outcomes, for which prospective epidemiologic research is limited. HAPCO will facilitate research to address public health concerns associated with HAP-attributed exposures by enabling investigators to evaluate sex-specific and smoking status-specific effects under various exposure scenarios.
家庭空气污染（HAP）是一个公共卫生问题，全球约有30亿人暴露于其中（包括美国的1500多万人）。燃煤产生的家庭空气污染是一种人类肺癌致癌物，但关于主要由木材等生物质使用所产生的家庭空气污染致癌性的流行病学证据并不确凿。为了有力地评估生物质的致癌潜力，需要对经历各种家庭空气污染暴露的个体进行前瞻性研究。我们组建了一个由13个前瞻性队列组成的全球联盟（HAPCO：家庭空气污染联盟），这些队列拥有特定地点和疾病的死亡率以及固体燃料使用数据，样本总量为587257名参与者，死亡人数为57483人。HAPCO提供了一个新的机会，在控制烟草和室外空气污染暴露等重要混杂因素的同时，评估家庭空气污染与肺癌死亡之间的关联。HAPCO在确定除肺癌之外的其他癌症以及非恶性呼吸和心脏代谢结局相关风险方面也具有独特优势，而针对这些方面的前瞻性流行病学研究有限。HAPCO将通过使研究人员能够评估不同暴露情景下的性别特异性和吸烟状态特异性影响，促进相关研究，以解决与家庭空气污染所致暴露相关的公共卫生问题。
