Jary Hannah, Simpson Hope, Havens Deborah, Manda Geoffrey, Pope Daniel, Bruce Nigel, Mortimer Kevin
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
PLoS One. 2016 Dec 1;11(12):e0167656. doi: 10.1371/journal.pone.0167656. eCollection 2016.
Household air pollution from solid fuel burning kills over 4 million people every year including half a million children from acute lower respiratory infections. Although biologically plausible, it is not clear whether household air pollution is also associated with acute lower respiratory infections in adults. We systematically reviewed the literature on household air pollution and acute lower respiratory infection in adults to identify knowledge gaps and research opportunities.
Ten bibliographic databases were searched to identify studies of household air pollution and adult acute lower respiratory infection. Data were extracted from eligible studies using standardised forms.
From 4617 titles, 513 abstracts and 72 full-text articles were reviewed. Eight studies met the inclusion criteria of which 2 found a significant adjusted increased risk of acute lower respiratory infection, 2 identified a univariate association whilst 4 found no significant association. Study quality was generally limited. Heterogeneity in methods and findings precluded meta-analysis.
A systematic review of the literature found limited evidence for an association between household air pollution and risk of acute lower respiratory infection in adults. Additional research, with carefully defined exposure and outcome measures, is required to complete the risk profile caused by household air pollution in adults.
CRD42015028042.
每年,固体燃料燃烧产生的家庭空气污染导致超过400万人死亡,其中包括50万因急性下呼吸道感染死亡的儿童。尽管从生物学角度看有合理性,但尚不清楚家庭空气污染是否也与成人急性下呼吸道感染有关。我们系统地回顾了关于家庭空气污染与成人急性下呼吸道感染的文献,以找出知识空白和研究机会。
检索了10个书目数据库,以确定关于家庭空气污染和成人急性下呼吸道感染的研究。使用标准化表格从符合条件的研究中提取数据。
共检索了4617篇标题、513篇摘要和72篇全文文章。8项研究符合纳入标准,其中2项研究发现急性下呼吸道感染的校正风险显著增加,2项研究确定了单变量关联,而4项研究未发现显著关联。研究质量普遍有限。方法和结果的异质性排除了进行荟萃分析的可能性。
对文献的系统评价发现,家庭空气污染与成人急性下呼吸道感染风险之间的关联证据有限。需要进行更多研究,仔细定义暴露和结局测量指标,以完善家庭空气污染对成人造成的风险概况。
CRD42015028042。