Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Oncology | IMED Biotech Unit, AstraZeneca, Darwin Building, Unit 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, United Kingdom.
Chem Rev. 2020 Mar 11;120(5):2613-2692. doi: 10.1021/acs.chemrev.9b00462. Epub 2020 Feb 17.
Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from simple, readily available feedstocks have become a cornerstone of modern synthetic organic chemistry. In light of the ever-increasing importance of aliphatic amines across the range of chemical sciences, this review aims to provide a concise overview of modern transition-metal catalyzed approaches to alkylamine synthesis and their functionalization. Selected examples of amine bond forming reactions include: (a) hydroamination and hydroaminoalkylation, (b) transition-metal catalyzed C(sp)-H functionalization, and (c) transition-metal catalyzed visible-light-mediated light photoredox catalysis.
过渡金属催化反应能够将简单易得的原料构建成复杂的脂肪族胺，已经成为现代合成有机化学的基石。鉴于脂肪族胺在化学科学各个领域的重要性日益增加，本文旨在提供现代过渡金属催化烷基胺合成及其功能化方法的简要概述。胺键形成反应的一些例子包括：(a) 氢胺化和氢氨烷基化，(b) 过渡金属催化 C(sp)-H 官能化，以及(c) 过渡金属催化可见光介导的光氧化还原催化。
