Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Center, University of Granada, Granada, Spain.
College of Food Science and Technology, Northwest University, Xi'an, China.
Antioxid Redox Signal. 2020 Oct 20;33(12):860-881. doi: 10.1089/ars.2020.8051. Epub 2020 Mar 25.
Cancer is related to redox biology from many points of view, such as initiation and promotion, metabolism and growth, invasion and metastasis, vascularization, or through the interaction with the immune system. In addition, this extremely complex relationship depends on the redox homeostasis of each cellular compartment, which might be used to fight cancer. New ways of modulating specific and little explored aspects of redox biology have been revealed, as well as new delivery methods or uses of previously known treatments against cancer. Here, we review the latest experimental evidence regarding redox biology in cancer treatment and analyze its potential impact in the development of improved and more effective antineoplastic therapies. A critical issue that deserves particular attention is the understanding that both extremes of redox biology (, oxidative stress [OS] and reductive stress) might be useful or harmful in relation to cancer prevention and treatment. Additional research is needed to understand how to selectively induce reductive or OS adequately to avoid cancer proliferation or to induce cancer cell death.
从多个角度来看，癌症与氧化还原生物学有关，例如启动和促进、代谢和生长、侵袭和转移、血管生成，或通过与免疫系统的相互作用。此外，这种极其复杂的关系取决于每个细胞区室的氧化还原稳态，可以用其来对抗癌症。已经揭示了调节氧化还原生物学特定和鲜为人知方面的新方法，以及新的输送方法或以前用于治疗癌症的已知治疗方法的新用途。在这里，我们回顾了关于癌症治疗中氧化还原生物学的最新实验证据，并分析了其在开发改进和更有效的抗肿瘤疗法方面的潜在影响。一个值得特别关注的关键问题是，理解氧化还原生物学的两个极端（氧化应激[OS]和还原应激）在癌症预防和治疗方面可能是有益的或有害的。需要进一步的研究来了解如何选择性地诱导适当的还原或 OS，以避免癌症增殖或诱导癌细胞死亡。
