Department of Vitreo-Retina Services, Aravind Eye Hospitals & Postgraduate Institute of Ophthalmology, Coimbatore, India.
Eur J Ophthalmol. 2021 May;31(3):NP70-NP73. doi: 10.1177/1120672120907317. Epub 2020 Feb 16.
A number of systemic medications are known to cause macular toxicity, and bull's eye maculopathy is caused by some of them like hydroxychloroquine and clofazimine. A 55-year-old female, known case of vitiligo with history of undergoing methoxsalen-ultraviolet A therapy, presented with painless defective vision in both eyes. Fundus examination and autofluorescence showed macular degeneration with bull's eye configuration. Optical coherence tomography showed perifoveal loss of photoreceptors and outer retinal thinning with foveal sparing appearing as 'flying saucer'. Multifocal electroretinogram showed pan-macular suppression of waveforms. Patient was diagnosed as case of methoxsalen-induced advanced macular toxicity. This is the first reported case of methoxsalen-induced advanced bull's eye maculopathy.
一些系统性药物已知会引起黄斑毒性，而某些药物如羟氯喹和氯法齐明会导致牛眼黄斑病变。一位 55 岁的女性，患有白癜风，曾接受甲氧沙林-紫外线 A 治疗，出现双眼无痛性视力缺陷。眼底检查和自发荧光显示黄斑变性，呈牛眼状。光学相干断层扫描显示中心凹周围的光感受器丧失和外视网膜变薄，而中心凹保持不变，呈现“飞碟”样外观。多焦视网膜电图显示全黄斑波形抑制。患者被诊断为甲氧沙林引起的晚期黄斑毒性。这是首例报道的甲氧沙林引起的晚期牛眼黄斑病变。
