Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, 1336616351, Iran.
Retina & Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Med Case Rep. 2023 Mar 26;17(1):110. doi: 10.1186/s13256-023-03868-3.
To report the first case of bull's eye maculopathy associated with veterinary niclosamide.
A 27-year-old Iranian female presented with a history of reduced vision and photopsia since 3 years, after accidental ingestion of four boluses of veterinary niclosamide. Fundus examination showed atrophy in parafoveal retinal pigmentary epithelium, appearing as bilateral bull's-eye maculopathy. Optical coherence tomography revealed disruption of the parafoveal ellipsoid zone and outer retinal thinning, appearing as a flying saucer sign. Electroretinography displayed decreased scotopic and photopic amplitudes with normal waveform in both eyes. The causality score was 4, showing "possible" retinopathy due to niclosamide according to Naranjo's causality assessment algorithm. Based on clinical and ancillary findings, a diagnosis of niclosamide-induced maculopathy was made.
Veterinary niclosamide is an anthelmintic drug that in higher doses could be detrimental to the human retina. Awareness about its side effects and appropriate drug labeling could prevent accidental toxicity.
报告首例与兽医用氯硝柳胺相关的牛眼样黄斑病变。
一名 27 岁的伊朗女性，因意外摄入四片兽医用氯硝柳胺，3 年前开始出现视力下降和光幻视。眼底检查显示中心凹旁视网膜色素上皮萎缩，呈现双侧牛眼样黄斑病变。光学相干断层扫描显示中心凹旁椭圆体带和外视网膜变薄，呈现飞碟征。视网膜电图显示双眼暗适应和明适应振幅降低，波形正常。根据 Naranjo 因果关系评估算法，因果关系评分为 4 分，提示氯硝柳胺引起的“可能”视网膜病变。基于临床和辅助检查结果，诊断为氯硝柳胺诱导的黄斑病变。
兽医用氯硝柳胺是一种驱虫药，高剂量可能对人眼有害。提高对其副作用的认识和适当的药物标签可以预防意外毒性。
