Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, NL, Mexico.
Expert Opin Drug Deliv. 2020 Mar;17(3):341-356. doi: 10.1080/17425247.2020.1727441. Epub 2020 Feb 17.
: Current treatments for osteogenic disorders are often successful, however they are not free of drawbacks, such as toxicity or side effects. Nanotechnology offers a platform for drug delivery in the treatment of bone disorders, which can overcome such limitations. Nevertheless, traditional synthesis of nanomaterials presents environmental and health concerns due to its production of toxic by-products, the need for extreme and harsh raw materials, and their lack of biocompatibility over time.: This review article contains an overview of the current status of treating osteogenic disorders employing green nanotechnological approaches, showing some of the latest advances in the application of green nanomaterials, as drug delivery carriers, for the effective treatment of osteogenic disorders.: Green nanotechnology, as a potential solution, is understood as the use of living organisms, biomolecules and environmentally friendly processes for the production of nanomaterials. Nanomaterials derived from bacterial cultures or biomolecules isolated from living organisms, such as carbohydrates, proteins, and nucleic acids, have been proven to be effective composites. These nanomaterials introduce enhancements in the treatment and prevention of osteogenic disorders, compared to physiochemically-synthesized nanostructures, specifically in terms of their improved cell attachment and proliferation, as well as their ability to prevent bacterial adhesion.
目前治疗成骨障碍的方法通常是有效的，但它们并非没有缺点，例如毒性或副作用。纳米技术为治疗骨疾病的药物输送提供了一个平台，可以克服这些限制。然而，由于其生产有毒副产品、需要极端和苛刻的原材料以及缺乏生物相容性，传统的纳米材料合成存在环境和健康问题。
这篇综述文章概述了使用绿色纳米技术方法治疗成骨障碍的现状，展示了绿色纳米材料在药物输送载体方面的最新应用进展，为成骨障碍的有效治疗提供了新的思路。
绿色纳米技术被理解为使用生物体、生物分子和环保工艺来生产纳米材料。已经证明，源自细菌培养物或从生物体中分离出的生物分子（如碳水化合物、蛋白质和核酸）的纳米材料是有效的复合材料。与物理化学合成的纳米结构相比，这些纳米材料在治疗和预防成骨障碍方面具有优势，特别是在改善细胞附着和增殖以及防止细菌附着方面。
