Department of Orthopaedics, Shaoxing People's Hospital, (Shaoxing Hospital, Zhejiang University School of Medicine), 568# Zhongxing North Road, Shaoxing 312000, Zhejiang Province, China.
Department of Traumatic Orthopedics, Affiliated Jinan Third Hospital of Jining Medical University, Jinan 250132, Shandong Province, China.
Curr Top Med Chem. 2020;20(30):2801-2819. doi: 10.2174/1568026620666201019110459.
Nanotechnology and its allied modalities have brought revolution in tissue engineering and bone healing. The research on translating the findings of the basic and preclinical research into clinical practice is ongoing. Advances in the synthesis and design of nanomaterials along with advances in genomics and proteomics, and tissue engineering have opened a bright future for bone healing and orthopedic technology. Studies have shown promising outcomes in the design and fabrication of porous implant substrates that can be exploited as bone defect augmentation and drug-carrier devices. However, there are dozens of applications in orthopedic traumatology and bone healing for nanometer-sized entities, structures, surfaces, and devices with characteristic lengths ranging from tens 10s of nanometers to a few micrometers. Nanotechnology has made promising advances in the synthesis of scaffolds, delivery mechanisms, controlled modification of surface topography and composition, and biomicroelectromechanical systems. This study reviews the basic and translational sciences and clinical implications of the nanotechnology in tissue engineering and bone diseases. Recent advances in NPs assisted osteogenic agents, nanocomposites, and scaffolds for bone disorders are discussed.
纳米技术及其相关模式在组织工程和骨愈合方面带来了革命。将基础和临床前研究的发现转化为临床实践的研究正在进行中。纳米材料的合成和设计的进步，以及基因组学和蛋白质组学的进步，以及组织工程，为骨愈合和矫形技术开辟了美好的未来。研究表明，设计和制造多孔植入物基质具有很大的潜力，可以作为骨缺损增强和药物载体装置。然而，在骨科创伤学和骨愈合方面，有数十种应用涉及纳米级实体、结构、表面和具有数十到数百微米特征长度的装置。纳米技术在支架的合成、输送机制、表面形貌和组成的控制修饰以及生物机电系统方面取得了有希望的进展。本研究综述了组织工程和骨病中纳米技术的基础和转化科学及临床意义。讨论了纳米粒子辅助成骨剂、纳米复合材料和用于骨疾病的支架的最新进展。
