Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
Stanford Cardiovascular Institute, Stanford, CA, USA.
Expert Opin Drug Deliv. 2021 Jun;18(6):715-736. doi: 10.1080/17425247.2021.1865306. Epub 2021 Apr 26.
: Current brain cancer treatments, based on radiotherapy and chemotherapy, are sometimes successful, but they are not free of drawbacks.: Traditional methods for the treatment of brain tumors are discussed here with new solutions presented, among which the application of nanotechnology has demonstrated promising results over the past decade. The traditional synthesis of nanostructures, which relies on the use of physicochemical methodologies are discussed, and their associated concerns in terms of environmental and health impact due to the production of toxic by-products, need for toxic catalysts, and their lack of biocompatibility are presented. An overview of the current situation for treating brain tumors using nanotechnological-based approaches is introduced, and some of the latest advances in the application of green nanomaterials (NMs) for the effective targeting of brain tumors are presented.: Green nanotechnology is introduced as a potential solution to toxic NMs through the application of environmentally friendly and cost-effective protocols using living organisms and biomolecules. The current status of this field, such as those involving clinical trials, is included, and the possible limitations of green-NMs and potential ways to avoid those limitations are discussed so that the field can potentially evolve.
目前的脑癌治疗方法基于放疗和化疗，有时是成功的，但并非没有缺点。
这里讨论了传统的脑瘤治疗方法，并提出了新的解决方案，其中纳米技术的应用在过去十年中显示出了有前途的结果。讨论了传统的纳米结构合成方法，这些方法依赖于使用物理化学方法，同时也提出了由于生产有毒副产品、需要有毒催化剂以及缺乏生物相容性而产生的环境和健康影响方面的相关问题。介绍了使用基于纳米技术的方法治疗脑肿瘤的现状，并介绍了一些最新进展，包括绿色纳米材料（NMs）在脑肿瘤有效靶向治疗中的应用。
绿色纳米技术作为解决有毒纳米材料的一种潜在方法被引入，其应用涉及使用生物体和生物分子的环保且具有成本效益的方案。包括该领域的现状，例如临床试验，并讨论了绿色-NMs 的可能局限性和潜在的避免这些局限性的方法，以便该领域可能会发展。
