Heier H E, Godal T
Scand J Haematol. 1977 Feb;18(2):149-53. doi: 10.1111/j.1600-0609.1977.tb02084.x.
Blood lymphocyte DNA synthesis, as expressed by 24-h uptake of 3H-thymidine in culture of mononuclear peripheral blood leucocytes has been reduced prior to treatment in 18 patients with Hodgkin's disease, 11 with non-leukaemic lymphosarcoma, 13 with reticulosarcoma and 20 with various solid tumors, and compared to 37 normal control subjects.The 3H-thymidine uptake was significantly increased in all the patient groups, but no significant difference existed between them. Increased uptake of 3H-thymidine did not appear to correlate with the degree of dissemination in any of the patient groups or with the presence or absence of general symptoms in malignant lymphoma. It is concluded that increased DNA synthesis in peripheral blood lymphocytes is a feature not limited to Hodgkin's disease, but found in non-Hodgkin's malignant lymphomas and other malignancies to about the same extent.
通过在单核外周血白细胞培养中3H-胸腺嘧啶核苷的24小时摄取量来表示的血液淋巴细胞DNA合成，在18例霍奇金病患者、11例非白血病性淋巴肉瘤患者、13例网状细胞肉瘤患者和20例各种实体瘤患者治疗前就已降低，并与37名正常对照受试者进行了比较。所有患者组中3H-胸腺嘧啶核苷的摄取量均显著增加，但各组之间无显著差异。3H-胸腺嘧啶核苷摄取量的增加似乎与任何患者组的播散程度无关，也与恶性淋巴瘤中全身症状的有无无关。结论是外周血淋巴细胞中DNA合成增加并非霍奇金病所特有，在非霍奇金恶性淋巴瘤和其他恶性肿瘤中也有大致相同程度的发现。
