de Pauw B E, Wagener D J, Smeulders J B, Geestman E J, Wessels J M, Haanen C
Br J Haematol. 1980 Mar;44(3):359-64. doi: 10.1111/j.1365-2141.1980.tb05904.x.
Density distribution profiles of peripheral lymphocytes were made in 41 untreated patients with Hodgkin's disease and in 14 normal controls. The fraction of lymphocytes with a low specific gravity in patients was significantly increased in comparison to normal controls (P=0.0007). These low density lymphocytes in Hodgkin's disease patients showed an elevated spontaneous 3H-thymidine incorporation compared to normal controls (P less than 0.0001). In 78% of the patients the spontaneous DNA synthesis of the low density lymphocytes was above the normal range. A positive correlation (P=0.002) was found between the spontaneous 3H-thymidine uptake and the stage of the disease.
对41例未经治疗的霍奇金病患者和14名正常对照者进行了外周淋巴细胞密度分布曲线分析。与正常对照相比，患者中低比重淋巴细胞的比例显著增加（P = 0.0007）。与正常对照相比，霍奇金病患者的这些低密度淋巴细胞显示出较高的自发3H-胸腺嘧啶核苷掺入率（P < 0.0001）。78%的患者中，低密度淋巴细胞的自发DNA合成高于正常范围。在自发3H-胸腺嘧啶核苷摄取与疾病分期之间发现正相关（P = 0.002）。
