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[神经母细胞瘤C1300细胞中N-酰基乙醇胺磷脂的检测]

[Detection of N-acylethanolamine phospholipids in neuroblastoma C1300 cells].

作者信息

Gulaia N M, Vas'kovskiĭ V E, Vysotskiĭ M V, Volkov G L, Govseeva N N

出版信息

Ukr Biokhim Zh (1978). 1988 Sep-Oct;60(5):58-63.

PMID:3206566
Abstract

Phospholipids with high chromatographic mobility are detected in cells of murine neuroblastoma C 1300. One of them is identified (proceeding from data of successive chemical degradation) as N-acylphosphatidylethanolamine. It may be a precursor of physiologically active N-acylethanolamines. N-palmitoyl and N-stearoylethanolamines are shown to inhibit the transport of ions through the veratrine-activated fast sodium channels as well as remove the effect of lysophospholipids accumulation in cells under the effect of veratrine.

摘要

在小鼠神经母细胞瘤C 1300细胞中检测到具有高色谱迁移率的磷脂。其中一种(根据连续化学降解的数据)被鉴定为N-酰基磷脂酰乙醇胺。它可能是生理活性N-酰基乙醇胺的前体。已表明N-棕榈酰基和N-硬脂酰基乙醇胺可抑制离子通过藜芦碱激活的快速钠通道的转运,并消除藜芦碱作用下细胞中溶血磷脂积累的影响。

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