Gulaia N M, Vas'kovskiĭ V E, Vysotskiĭ M V, Volkov G L, Govseeva N N
Ukr Biokhim Zh (1978). 1988 Sep-Oct;60(5):58-63.
Phospholipids with high chromatographic mobility are detected in cells of murine neuroblastoma C 1300. One of them is identified (proceeding from data of successive chemical degradation) as N-acylphosphatidylethanolamine. It may be a precursor of physiologically active N-acylethanolamines. N-palmitoyl and N-stearoylethanolamines are shown to inhibit the transport of ions through the veratrine-activated fast sodium channels as well as remove the effect of lysophospholipids accumulation in cells under the effect of veratrine.
在小鼠神经母细胞瘤C 1300细胞中检测到具有高色谱迁移率的磷脂。其中一种(根据连续化学降解的数据)被鉴定为N-酰基磷脂酰乙醇胺。它可能是生理活性N-酰基乙醇胺的前体。已表明N-棕榈酰基和N-硬脂酰基乙醇胺可抑制离子通过藜芦碱激活的快速钠通道的转运,并消除藜芦碱作用下细胞中溶血磷脂积累的影响。