Pradhan Sourav, Mishra Manmath, De Pinaki Bhusan, Banerjee Sonbidya, Punniyamurthy Tharmalingam
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Org Lett. 2020 Mar 6;22(5):1720-1725. doi: 10.1021/acs.orglett.9b04612. Epub 2020 Feb 17.
A weak carbonyl coordination facilitated tunable reactivity between alkenylation and alkylation of indoles at the C4 C-H site is presented using readily accessible allylic alcohols in the presence of Rh catalysis by switching the additives or directing group. Exclusive site selectivity, functional group tolerance, and late-stage modifications are the important practical features.
利用易于获得的烯丙醇，在铑催化下，通过改变添加剂或导向基团，实现了弱羰基配位促进吲哚在C4 C-H位点烯基化和烷基化之间的可调反应性。独特的位点选择性、官能团耐受性和后期修饰是重要的实际特点。
