细菌膜如何抵抗多黏菌素类抗生素？

Department of Physics and Astronomy, McMaster University, Hamilton, ON, Canada.

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Commun Biol. 2020 Feb 17;3(1):77. doi: 10.1038/s42003-020-0803-x.

In our recent Communications Biology article, we reported on the biophysical mechanism of resistance for polymyxin antibiotics in bacterial membranes. The emergence of plasmid-borne colistin resistance poses a threat to our last line of defense against many pathogens. Here, we outline the current understanding of -mediated polymyxin resistance, and propose future directions for membrane-targeting antibiotic research.

在我们最近发表于《通讯生物学》的文章中，我们报告了多黏菌素类抗生素在细菌膜中产生耐药性的生物物理机制。质粒介导的黏菌素耐药性的出现，对我们对抗许多病原体的最后一道防线构成了威胁。在这里，我们概述了目前对介导的多黏菌素耐药性的理解，并为靶向膜的抗生素研究提出了未来的方向。