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本文引用的文献

1
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.预测与口服剂量和血液浓度相关的人体药物性肝损伤（DILI）。
Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27.
2
Road Map for Development of Stem Cell-Based Alternative Test Methods.基于干细胞的替代测试方法发展路线图。
Trends Mol Med. 2019 Jun;25(6):470-481. doi: 10.1016/j.molmed.2019.04.003. Epub 2019 May 23.
3
Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing.基于生理的从头生物动力学建模作为动物测试的替代方法。
ALTEX. 2019;36(4):597-612. doi: 10.14573/altex.1812051. Epub 2019 May 10.
4
Compound selection and annotation to validate the predictivity of in vitro toxicity assays for use in drug discovery, in response to Commentary by Dr. Zink (Zink, D. Arch Toxicol (2018)).化合物的选择与注释，以验证体外毒性试验在药物发现中的预测性，回应津克博士的评论（津克，D.《毒理学文献》（2018年））
Arch Toxicol. 2019 Jan;93(1):225-226. doi: 10.1007/s00204-018-2359-9. Epub 2018 Dec 11.
5
Comment on Sjögren et al. (2018) A novel multi-parametric high-content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity in drug discovery. Arch Toxicol 92(10):3175-3190.评论 Sjögren 等人（2018 年）：ciPTEC-OAT1 中的新型多参数高通量筛选测定法可预测药物发现中的药物诱导肾毒性。毒理学档案 92（10）：3175-3190。
Arch Toxicol. 2019 Jan;93(1):221-223. doi: 10.1007/s00204-018-2327-4. Epub 2018 Oct 17.
6
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.原代人肝细胞细胞毒性试验中潜伏期的相关性。
Arch Toxicol. 2018 Dec;92(12):3505-3515. doi: 10.1007/s00204-018-2302-0. Epub 2018 Oct 13.
7
A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery.一种新型的 ciPTEC-OAT1 多参数高内涵筛选测定法，用于在药物发现过程中预测药物诱导的肾毒性。
Arch Toxicol. 2018 Oct;92(10):3175-3190. doi: 10.1007/s00204-018-2284-y. Epub 2018 Aug 24.
8
Characterization of hepatocyte-based in vitro systems for reliable toxicity testing.用于可靠毒性测试的基于肝细胞的体外系统的表征。
Arch Toxicol. 2018 Oct;92(10):2981-2986. doi: 10.1007/s00204-018-2297-6. Epub 2018 Aug 23.
9
Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology.用于评估心脏病理学变化的人类 3D 心脏微组织的特征描述和验证。
Sci Rep. 2018 Jul 5;8(1):10160. doi: 10.1038/s41598-018-28393-y.
10
Adverse outcome pathways: opportunities, limitations and open questions.不良结局途径：机遇、局限性和未解决问题。
Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19.

In vitro prediction of organ toxicity: the challenges of scaling and secondary mechanisms of toxicity.

作者信息

Hengstler Jan G, Sjögren Anna-Karin, Zink Daniele, Hornberg Jorrit J

机构信息

IfADo at TU Dortmund, Dortmund, Germany.

Cardiovascular, Renal and Metabolism Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

出版信息

Arch Toxicol. 2020 Feb;94(2):353-356. doi: 10.1007/s00204-020-02669-7. Epub 2020 Feb 17.

DOI:10.1007/s00204-020-02669-7
PMID:32067068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8211595/
Abstract
摘要