妊娠合并复杂胆囊疾病与不良母婴结局的相关性。
Association of complicated gallstone disease in pregnancy and adverse birth outcomes.
机构信息
Trauma Service, Scripps Mercy Hospital, 4077 Fifth Avenue, San Diego, CA, 92103, USA.
Department of Obstetrics and Gynecology, Scripps Mercy Hospital, 4077 Fifth Avenue, San Diego, CA, 92103, USA.
出版信息
Am J Surg. 2020 Sep;220(3):745-750. doi: 10.1016/j.amjsurg.2020.01.038. Epub 2020 Jan 24.
BACKGROUND
Complicated gallstone disease (CGD) is a common condition requiring intervention during pregnancy to avert adverse birth outcomes (ABO).
METHODS
Cohort study using the California OSHPD 2007-2014 database. Records of pregnant patients were analyzed for gallbladder calculus within four months of delivery. Biliary system interventions were evaluated as the primary exposure.
RESULTS
Of 7,597 patients, those with CGD had a greater likelihood of biliary system procedures than those with uncomplicated gallstone disease (36.6% vs. 2.5%, p < 0.001). Patients with CGD also had increased odds of ABO (OR 2.02, 95% CI, 1.48-2.76). Compared to patients without biliary system procedures, those with interventions for gallstones had an OR of 3.46 (95% CI, 2.48-4.82) for ABO. After adjustment, biliary system intervention for CGD had an even greater risk of ABO (OR 4.26, 95% CI, 2.86-6.35).
CONCLUSIONS
The risk of ABO is significantly increased in women with CGD and intervention for gallstones.
背景
复杂胆石病（CGD）是一种常见疾病，在妊娠期间需要干预以避免不良母婴结局（ABO）。
方法
使用加利福尼亚 OSHPD 2007-2014 数据库进行队列研究。分析分娩后四个月内有胆囊结石的孕妇记录。胆道系统干预被评估为主要暴露因素。
结果
在 7597 名患者中，CGD 患者行胆道系统手术的可能性大于无复杂胆石病患者（36.6% vs. 2.5%，p<0.001）。CGD 患者 ABO 的发生几率也更高（OR 2.02，95%CI，1.48-2.76）。与无胆道系统手术的患者相比，行胆道系统结石干预的患者 ABO 的 OR 为 3.46（95%CI，2.48-4.82）。调整后，CGD 的胆道系统干预 ABO 的风险甚至更高（OR 4.26，95%CI，2.86-6.35）。
结论
CGD 患者和胆石症干预的 ABO 风险显著增加。
Zotero 插件