Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Nuclear Architecture in Neural Plasticity and Aging, German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Exp Gerontol. 2020 May;133:110876. doi: 10.1016/j.exger.2020.110876. Epub 2020 Feb 14.
The human brain is affected by cellular aging. Neurons are primarily generated during embryogenesis and early life with a limited capacity for renewal and replacement, making them some of the oldest cells in the human body. Our present understanding of neurodegenerative diseases points towards advanced neuronal age as a prerequisite for the development of these disorders. While significant progress has been made in understanding the relationship between aging and neurological disease, it will be essential to delve further into the molecular mechanisms of neuronal aging in order to develop therapeutic interventions targeting age-related brain dysfunction. In this mini review, we highlight recent findings on the relationship between the aging of nuclear structures and changes in the epigenetic landscape during neuronal aging and disease.
人类大脑受到细胞衰老的影响。神经元主要在胚胎发生和生命早期生成，其更新和替换能力有限，因此成为人体中最古老的细胞之一。我们目前对神经退行性疾病的理解表明，神经元的高龄是这些疾病发展的前提。虽然我们在理解衰老与神经疾病之间的关系方面已经取得了重大进展，但深入研究神经元衰老的分子机制对于开发针对与年龄相关的大脑功能障碍的治疗干预措施至关重要。在这篇简短的综述中，我们强调了最近在核结构衰老与神经元衰老和疾病期间表观遗传景观变化之间关系的发现。
