病毒感染对小胶质细胞和加速大脑衰老的影响。
The Influence of Virus Infection on Microglia and Accelerated Brain Aging.
机构信息
Anatomy, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
出版信息
Cells. 2021 Jul 20;10(7):1836. doi: 10.3390/cells10071836.
Abstract
Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging.
摘要
小胶质细胞是中枢神经系统的固有免疫细胞，对健康和疾病有重要贡献。越来越多的证据表明，炎症性小胶质细胞可能通过干扰生理修复和重塑过程，诱导或加速大脑衰老。许多病毒感染会影响大脑并干扰小胶质细胞的功能，包括人类免疫缺陷病毒、黄病毒、SARS-CoV-2、流感病毒和人类疱疹病毒。特别是导致低度神经炎症的慢性病毒感染，可能导致大脑衰老。本综述阐述了各种神经嗜性病毒在小胶质细胞驱动的神经认知缺陷和可能加速大脑衰老中的潜在作用。
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