Gonzalez-Lucano Luis Renee, Vasquez-Armenta Gabriela Vazquez, Pereira-Suarez Ana Laura, Ramirez-de Arellano Adrian, Ramirez-de Los Santos Saul, Lopez-Pulido Edgar Ivan
Tecnológico de Monterrey, Campus Guadalajara, Zapopan, Jalisco, México.
Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
J Infect Dev Ctries. 2019 Aug 31;13(8):764-767. doi: 10.3855/jidc.11424.
Epstein-Barr Virus (EBV) infection prevails in underdeveloped and developing countries. The tonsils seem to be candidate replication sites for EBV and some studies have exposed a close association among viral infections and chronic tonsillitis. The objective of this study was identifying the EBV prevalence in Mexican patients who had undergone tonsillectomy because of chronic tonsillitis.
Frozen tissues and medical records were obtained from 50 Mexican patients. DNA was extracted and subjected to PCR to amplify the EBER-2 region of EBV. Next, the patients were classified according to general and clinical characteristics searching a relation with the EBV-DNA positivity.
EBV genome was detected in 46% (23/50) of the analysed tonsil tissues. Trends were found regarding the relationship of viral presence with lower values in terms of age (6.1 ± 2.8 vs 7.6 ± 3.7) , a greater degree of hypertrophy (3.5 ± 0.4 vs 3.0 ± 0.6) and an increase in the number of episodes of tonsillitis (11 ± 7.4 vs 9 ± 6.5).
The prevalence found of EBV-DNA positivity in tonsillar tissues from patients diagnosed with chronic tonsillitis , supports the fact that palatine tonsils can be occupied by EBV and highlights the importance of conducting future studies focused on understanding the role of the EBV infection in chronic inflammatory processes in the population involved in this study.
爱泼斯坦-巴尔病毒（EBV）感染在不发达国家和发展中国家普遍存在。扁桃体似乎是EBV的候选复制位点，一些研究揭示了病毒感染与慢性扁桃体炎之间的密切关联。本研究的目的是确定因慢性扁桃体炎接受扁桃体切除术的墨西哥患者中EBV的流行情况。
从50名墨西哥患者处获取冷冻组织和病历。提取DNA并进行PCR以扩增EBV的EBER-2区域。接下来，根据一般和临床特征对患者进行分类，寻找与EBV-DNA阳性的关系。
在46%（23/50）的分析扁桃体组织中检测到EBV基因组。发现病毒存在与年龄较低值（6.1±2.8对7.6±3.7）、更大程度的肥大（3.5±0.4对3.0±0.6）以及扁桃体炎发作次数增加（11±7.4对9±6.5）之间存在相关趋势。
在诊断为慢性扁桃体炎的患者扁桃体组织中发现的EBV-DNA阳性率，支持腭扁桃体可被EBV占据这一事实，并突出了开展未来研究以了解EBV感染在本研究涉及人群的慢性炎症过程中的作用的重要性。
