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宫腔镜腹腔镜联合手术治疗子宫内膜异位症相关性不孕的手术益处:一项至少随访2年的单中心回顾性研究

The Surgical Benefit of Hysterolaparoscopy in Endometriosis-Related Infertility: A Single Centre Retrospective Study with a Minimum 2-Year Follow-Up.

作者信息

Ekine Atombosoba Adokiye, Fülöp István, Tekse István, Rúcz Árpád, Jeges Sara, Koppán Ágnes, Koppán Miklós

机构信息

Department of Obstetrics & Gynaecology, Robert Károly Private Hospital, 1135 Budapest, Hungary.

Faculty of Health Sciences, University of Pécs, 48-as tér 1, 7622 Pécs, Hungary.

出版信息

J Clin Med. 2020 Feb 13;9(2):507. doi: 10.3390/jcm9020507.

Abstract

AIM

This study examined the fertility performance of women after combined hysterolaparoscopic surgical management of endometriosis. This study is a hospital-based retrospective review.

MATERIALS AND METHODS

Data collected from the records of all patients presented with endometriosis-related infertility using a checklist designed for the purpose. A total of 81.3% (370/455) of women who have had the desire to have children became pregnant during the study period after the surgery. Of those who became pregnant, all three-hundred-forty-seven patients were followed to the end of their pregnancies. A successful live birth occurred in 94.2% (327/347) of individuals, and pregnancy loss occurred in 5.8% (20/347). The mean patient age was 34.1 ± 4.1 years, and the average duration of infertility was 3.4 ± 3.3 years. Pregnancy occurred spontaneously in 39.5% (146/370) of patients, after artificial insemination (AIH) in 3.8% (14/370) of women, and after in vitro fertilization-embryo transfer (IVF-ET) in 56.8% (210/370) of cases. Patients aged ≤ 35 years had a higher chance of conception post-surgery-84% versus 77%, respectively ( = 0.039). Based on the modes of pregnancy, the timely introduction of an assisted reproductive technique (ART) demonstrated a significant effect on fertility performance postsurgery. Comparatively, this effect was 91.3% vs. 74.1% among the ≤35- and >35-year-old age groups, respectively. There was no significant difference in reproductive performance based on stages of endometriosis, nor in the other parameters evaluated. Our data are consistent with previous clinical studies regarding the management options of endometriosis-related infertility. Overall, the combined hysterolaparoscopy treatment is a very effective and reliable procedure, and is even more effective when combined with ART. It enhances women's wellbeing and quality of life, and significantly improves reproductive performance.

摘要

目的

本研究探讨了子宫内膜异位症经宫腔镜腹腔镜联合手术治疗后女性的生育情况。本研究是一项基于医院的回顾性研究。

材料与方法

使用专门为此目的设计的检查表,从所有患有子宫内膜异位症相关性不孕患者的记录中收集数据。在研究期间,共有81.3%(370/455)有生育意愿的女性在手术后怀孕。在那些怀孕的患者中,347名患者均被随访至妊娠结束。94.2%(327/347)的个体成功活产,5.8%(20/347)发生妊娠丢失。患者平均年龄为34.1±4.1岁,平均不孕时间为3.4±3.3年。39.5%(146/370)的患者自然受孕,3.8%(14/370)的女性在人工授精(AIH)后受孕,56.8%(210/370)的病例在体外受精-胚胎移植(IVF-ET)后受孕。年龄≤35岁的患者术后受孕几率更高——分别为84%和77%(P = 0.039)。基于妊娠方式,及时引入辅助生殖技术(ART)对术后生育情况有显著影响。相比之下,在≤35岁和>35岁年龄组中,这种影响分别为91.3%和74.1%。基于子宫内膜异位症的分期,生殖性能以及所评估的其他参数均无显著差异。我们的数据与先前关于子宫内膜异位症相关性不孕治疗方案的临床研究一致。总体而言,宫腔镜腹腔镜联合治疗是一种非常有效且可靠的手术,与ART联合使用时效果更佳。它可提高女性的幸福感和生活质量,并显著改善生殖性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cf/7073634/be95cf282389/jcm-09-00507-g001.jpg

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