Clinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.
Department of Obstetrics and Gynecology, Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.
PLoS One. 2016 Apr 21;11(4):e0154227. doi: 10.1371/journal.pone.0154227. eCollection 2016.
Despite being quite frequent and having serious implications in terms of symptomatology and fertility, data on incidence and prevalence of endometriosis and adenomyosis following gold standard definitions are dramatically lacking. The average time from onset of symptoms to diagnosis in industrialized countries still ranges from five to ten years. Using the regional centralized data linkage system, we calculated incidence and prevalence of endometriosis and adenomyosis in the female population of Friuli Venezia Giulia region, Italy, for the years 2011-2013. Cases were defined as new diagnoses from hospital discharge records, following procedures allowing direct visualization for endometriosis and hysterectomy for adenomyosis, with or without histological confirmation. Diagnoses were considered "new" after verifying women had not been diagnosed in the previous ten years. Incidence of endometriosis and adenomyosis in women aged 15-50 years is 0.14%. Prevalence, estimated from incidence, is 2.00%. Adenomyosis, representing 28% of all diagnoses, becomes increasingly prevalent after the age of 50 years. Our results shows how the study of both endometriosis and adenomyosis should not be limited to women of premenopausal age. Further efforts are needed to sensitize women and health professional, and to find new data linkage possibilities to identify undiagnosed cases.
尽管子宫内膜异位症和子宫腺肌病的发病率很高，且在症状和生育能力方面存在严重影响，但按照金标准定义，有关这两种疾病的发病率和患病率的数据却严重缺乏。在工业化国家，从症状出现到确诊的平均时间仍在 5 至 10 年之间。我们利用区域性集中数据链接系统，计算了意大利弗留利-威尼斯朱利亚地区 2011 年至 2013 年期间女性中子宫内膜异位症和子宫腺肌病的发病率和患病率。通过医院出院记录中的新诊断病例来定义病例，这些诊断是通过允许直接观察子宫内膜异位症的程序以及针对子宫腺肌病的子宫切除术来做出的，无论是否有组织学确认。如果在过去十年中没有诊断过这些妇女，则认为诊断为“新”。15 至 50 岁女性的子宫内膜异位症和子宫腺肌病发病率为 0.14%。根据发病率估算的患病率为 2.00%。腺肌病占所有诊断的 28%，其患病率在 50 岁后逐渐增加。我们的研究结果表明，对子宫内膜异位症和子宫腺肌病的研究不应仅限于绝经前妇女。需要进一步努力提高妇女和卫生专业人员的认识，并寻找新的数据链接可能性，以发现未确诊的病例。
