Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmacol Res. 2020 May;155:104692. doi: 10.1016/j.phrs.2020.104692. Epub 2020 Feb 15.
Pre-eclampsia (PE) is a complication of pregnancy that is associated with mortality and morbidity in mothers and fetuses worldwide. Oxygen dysregulation in the placenta, abnormal remodeling of the spiral artery, defective placentation, oxidative stress at the fetal-maternal border, inflammation and angiogenic impairment in the maternal circulation are the main causes of this syndrome. These events result in a systemic and diffuse endothelial cell dysfunction, an essential pathophysiological feature of PE. The impact of bacteria on the multifactorial pathway of PE is the recent focus of scientific inquiry since microbes may cause each of the aforementioned features. Microbes and their derivatives by producing antigens and other inflammatory factors may trigger infection and inflammatory responses. A mother's bacterial communities in the oral cavity, gut, vagina, cervix and uterine along with the placenta and amniotic fluid microbiota may be involved in the development of PE. Here, we review the mechanistic and pathogenic role of bacteria in the development of PE. Then, we highlight the impact of alterations in a set of maternal microbiota (dysbiosis) on the pathogenesis of PE.
子痫前期（PE）是一种妊娠并发症，与全球范围内母亲和胎儿的死亡率和发病率有关。胎盘的氧气调节异常、螺旋动脉的异常重塑、胎盘形成不良、胎儿-母体边界的氧化应激、母体循环中的炎症和血管生成损伤是该综合征的主要原因。这些事件导致全身性和弥漫性内皮细胞功能障碍，这是 PE 的基本病理生理特征。由于微生物可能导致上述所有特征，因此细菌对 PE 的多因素途径的影响是当前科学研究的重点。微生物及其衍生物通过产生抗原和其他炎症因子，可能引发感染和炎症反应。母亲口腔、肠道、阴道、宫颈和子宫以及胎盘和羊水微生物群中的细菌可能参与了 PE 的发展。在这里，我们综述了细菌在 PE 发展中的机制和致病作用。然后，我们强调了一组母体微生物群（失调）改变对 PE 发病机制的影响。
