我们不应该在病毒在疾病爆发期间发生变异时感到担忧。
We shouldn't worry when a virus mutates during disease outbreaks.
机构信息
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.
Yale Institute for Global Health, Yale University, New Haven, CT, USA.
出版信息
Nat Microbiol. 2020 Apr;5(4):529-530. doi: 10.1038/s41564-020-0690-4.
Abstract
Mutation. The word naturally conjures fears of unexpected and freakish changes. Ill-informed discussions of mutations thrive during virus outbreaks, including the ongoing spread of SARS-CoV-2. In reality, mutations are a natural part of the virus life cycle and rarely impact outbreaks dramatically.
摘要
突变。这个词自然会让人联想到对意外和怪异变化的恐惧。在病毒爆发期间，包括 SARS-CoV-2 持续传播期间，对突变的讨论往往缺乏充分的信息。实际上，突变是病毒生命周期的自然组成部分，很少对疫情产生巨大影响。
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本文引用的文献
1
VIRULENCE.毒力
Evolution. 1994 Oct;48(5):1423-1437. doi: 10.1111/j.1558-5646.1994.tb02185.x.
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