Thompson David, Gasteau Damien, Manohar Srirang
Biomedical Photonic Imaging, Technical Medical Centre, University of Twente, The Netherlands.
Multi-Modality Medical Imaging Group (M3I), Technical Medical Centre, University of Twente, The Netherlands.
Photoacoustics. 2020 Jan 23;18:100154. doi: 10.1016/j.pacs.2019.100154. eCollection 2020 Jun.
This work presents spatially compounded plane wave imaging using a laser-induced ultrasound source. The plane wave source consisted of a 30 μm thick film of carbon black-doped PDMS cured on a 100 μm thick polyester substrate and presented a rectangular aperture of 40 × 3 mm. It was placed in front of a linear ultrasound array, passing through the imaging plane allowing overlap of the detection plane and the insonification plane. Illumination was provided by an array of optical fibre bundles placed above the imaging plane, at an angle. We will first present the general imaging set up and instrumentation used, after which details are given on the fabrication of the transmitter itself and on the objects that were imaged. Comparing laser-induced and conventional ultrasound images of wire phantoms shows the point-spread-function to be, in general, slightly better laterally in the conventional case but more homogeneous throughout the imaging plane with the laser-induced source. Imaging of a tissue-mimicking phantom shows a 55% improvement in contrast between a tumour and the background when using laser-induced ultrasound, as compared to the conventional case.
这项工作展示了使用激光诱导超声源的空间复合平面波成像。平面波源由固化在100μm厚聚酯基板上的30μm厚掺炭黑聚二甲基硅氧烷薄膜组成,呈现出40×3mm的矩形孔径。它放置在线性超声阵列前方,穿过成像平面,使检测平面和超声照射平面重叠。照明由以一定角度放置在成像平面上方的光纤束阵列提供。我们将首先介绍所使用的一般成像设置和仪器,之后详细说明发射器本身的制造以及所成像的物体。比较激光诱导和传统超声对金属丝仿体的成像表明,一般来说,传统情况下点扩散函数在横向略好,但在整个成像平面上激光诱导源的成像更均匀。与传统情况相比,使用激光诱导超声对组织仿体成像时,肿瘤与背景之间的对比度提高了55%。