Philip Morris International Research and Development, Philip Morris Products S.A, Quai Jeanrenaud 3, 2000, Neuchâtel, Switzerland.
Anal Bioanal Chem. 2020 Apr;412(11):2675-2685. doi: 10.1007/s00216-020-02502-1. Epub 2020 Feb 18.
A suite of untargeted methods has been applied for the characterization of aerosol from the Tobacco Heating System 2.2 (THS2.2), a heated tobacco product developed by Philip Morris Products S.A. and commercialized under the brand name IQOS®. A total of 529 chemical constituents, excluding water, glycerin, and nicotine, were present in the mainstream aerosol of THS2.2, generated by following the Health Canada intense smoking regimen, at concentrations ≥ 100 ng/item. The majority were present in the particulate phase (n = 402), representing more than 80% of the total mass determined by untargeted screening; a proportion were present in both particulate and gas-vapor phases (39 compounds). The identities for 80% of all chemical constituents (representing > 96% of the total determined mass) were confirmed by the use of authentic analytical reference materials. Despite the uncertainties that are recognized to be associated with aerosol-based untargeted approaches, the reported data remain indicative that the uncharacterized fraction of TPM generated by THS2.2 has been evaluated to the fullest practicable extent. To the best of our knowledge, this work represents the most comprehensive chemical characterization of a heated tobacco aerosol to date. Graphical abstract.
已应用一系列非靶向方法来描述加热烟草系统 2.2（THS2.2）产生的气溶胶，该系统由菲利普莫里斯产品公司开发，以 IQOS®品牌商业化。通过遵循加拿大卫生部重度吸烟方案生成的 THS2.2 主流气溶胶中，除水、甘油和尼古丁外，共存在 529 种化学物质，浓度≥100ng/项。这些物质大多数存在于颗粒相中（n=402），占非靶向筛选确定的总质量的 80%以上；一部分同时存在于颗粒相和气相中（39 种化合物）。使用真实分析参考物质对所有化学物质的 80%（占总确定质量的>96%）的身份进行了确认。尽管人们认识到基于气溶胶的非靶向方法存在不确定性，但报告的数据仍然表明，THS2.2 产生的 TPM 中未明确的部分已被尽可能全面地评估。据我们所知，这是迄今为止对加热烟草气溶胶进行的最全面的化学特征描述。
