Institute of Systems Biology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.
Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.
Planta. 2020 Feb 18;251(3):68. doi: 10.1007/s00425-020-03356-8.
The SCF complex is a widely studied multi-subunit ring E3 ubiquitin ligase that tags targeted proteins with ubiquitin for protein degradation by the ubiquitin 26S-proteasome system (UPS). The UPS is an important system that generally keeps cellular events tightly regulated by purging misfolded or damaged proteins and selectively degrading important regulatory proteins. The specificity of this post-translational regulation is controlled by F-box proteins (FBPs) via selective recognition of a protein-protein interaction motif at the C-terminal domain. Hence, FBPs are pivotal proteins in determining the plant response in multiple scenarios. It is not surprising that the FBP family is one of the largest protein families in the plant kingdom. In this review, the roles of FBPs, specifically in plants, are compiled to provide insights into their involvement in secondary metabolites, plant stresses, phytohormone signalling, plant developmental processes and miRNA biogenesis.
SCF 复合物是一种广泛研究的多亚基环 E3 泛素连接酶，它将靶蛋白与泛素标记，通过泛素 26S-蛋白酶体系统 (UPS) 进行蛋白质降解。UPS 是一个重要的系统，通常通过清除错误折叠或受损的蛋白质并选择性降解重要的调节蛋白来保持细胞事件的紧密调节。这种翻译后调节的特异性由 F-box 蛋白 (FBPs) 通过选择性识别 C 末端结构域中的蛋白质-蛋白质相互作用模体来控制。因此，FBPs 是在多种情况下决定植物反应的关键蛋白。FBP 家族是植物王国中最大的蛋白质家族之一，这并不奇怪。在这篇综述中，我们编译了 FBPs 的作用，特别是在植物中的作用，以深入了解它们在次生代谢物、植物应激、植物激素信号转导、植物发育过程和 miRNA 生物发生中的参与。
