Brunkwall Louise, Ericson Ulrika, Nilsson Peter M, Enhörning Sofia
Department of Clinical Sciences, Clinical Research Center, Jan Waldenströms gata 35, Lund University, 214 28, Malmö, Sweden.
Department of Endocrinology, Skåne University Hospital, Lund, Sweden.
Eur J Nutr. 2020 Dec;59(8):3715-3722. doi: 10.1007/s00394-020-02202-7. Epub 2020 Feb 18.
Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low urine volume and high urine osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water intake or high u-Osm correlated with high fp-copeptin and components of the metabolic syndrome at the population level.
In the population-based Malmö Offspring Study (MOS, n = 2599), fp-copeptin and u-Osm from morning urine samples were measured, and diet and total water intake (from beverages and food moisture) was assessed by a 4-day web-based record.
Increasing water intake by tertile was after adjustment for age and sex associated with low fp-triglycerides (p = 0.002) and high fp-HDL (p = 0.004), whereas there was no association with the other investigated metabolic traits (HbA1c, fp-glucose, BMI or waist circumference). Increasing u-Osm by tertile was, after adjustment for age and sex, associated with high fp-glucose (p = 0.007), and borderline significantly associated with high HbA1c (p = 0.053), but no association was observed with fp-HDL, fp-triglycerides, BMI or waist circumference. Fp-copeptin concentration correlated significantly with water intake (r = - 0.13, p < 0.001) and u-Osm (r = 0.27, p < 0.001). High copeptin was associated with all investigated metabolic traits (p < 0.001 for all).
Low concentrations of the vasopressin marker copeptin is linked to high water intake, low u-Osm, and a favorable metabolic profile, suggesting that vasopressin lowering lifestyle interventions, such as increased water intake, may promote metabolic health.
在人群水平上，血管加压素标志物 copeptin 的血浆浓度升高和低饮水量与血糖升高及糖尿病风险相关。此外，在尿量少且尿渗透压（u-Osm）高的个体中，补充水分可降低空腹血浆（fp）copeptin 和 fp-葡萄糖水平。在这项观察性研究中，我们调查了在人群水平上，低总饮水量或高 u-Osm 是否与高 fp-copeptin 及代谢综合征的组分相关。
在基于人群的马尔默后代研究（MOS，n = 2599）中，测量了晨尿样本中的 fp-copeptin 和 u-Osm，并通过基于网络的 4 天记录评估饮食和总饮水量（来自饮料和食物水分）。
按三分位数增加饮水量，在调整年龄和性别后，与低 fp-甘油三酯（p = 0.002）和高 fp-HDL（p = 0.004）相关，而与其他研究的代谢特征（糖化血红蛋白、fp-葡萄糖、体重指数或腰围）无关。按三分位数增加 u-Osm，在调整年龄和性别后，与高 fp-葡萄糖（p = 0.007）相关，与高糖化血红蛋白有边缘显著相关性（p = 0.053），但与 fp-HDL、fp-甘油三酯、体重指数或腰围无相关性。Fp-copeptin 浓度与饮水量显著相关（r = -0.13，p < 0.001）和 u-Osm（r = 0.27，p < 0.001）。高 copeptin 与所有研究的代谢特征相关（所有 p < 0.001）。
血管加压素标志物 copeptin 的低浓度与高饮水量、低 u-Osm 和良好的代谢谱相关，表明降低血管加压素的生活方式干预措施，如增加饮水量，可能促进代谢健康。
