Department of Genetics, Federal University of Parana, Curitiba, Parana, Brazil.
Laboratório de Genética Molecular Humana (Laboratory of Human Molecular Genetics), Department of Genetics, Federal University of Parana, Curitiba, Parana, Brazil.
Adv Exp Med Biol. 2020;1227:107-129. doi: 10.1007/978-3-030-36422-9_8.
The Notch signaling is a crucial pathway involved in cellular development, progression, and differentiation. Deregulation of Notch signaling pathway commonly impacts tissue homeostasis, being highly associated with proliferative disorders. The long noncoding RNAs (lncRNAs), which are transcripts with more than 200 nucleotides that do not code for proteins, were already described as Notch signaling pathway-interacting molecules. Many of them act as important transcriptional and posttranscriptional regulators, affecting gene expression and targeting other regulatory molecules, such as miRNAs. Due to their strong impact on function and gene expression of Notch-related molecules, lncRNAs influence susceptibility to cancer and other diseases, and can be regarded as potential biomarkers and therapeutic targets. Along this chapter, we summarize the cross talk between the Notch signaling pathway and their most important modulating lncRNAs, as well as the pathological consequences of these interactions, in different tissues.
Notch 信号通路是一个涉及细胞发育、进展和分化的关键途径。 Notch 信号通路的失调通常会影响组织的动态平衡，与增殖性疾病密切相关。长链非编码 RNA（lncRNA）是一种转录本，长度超过 200 个核苷酸，不编码蛋白质，已经被描述为 Notch 信号通路相互作用的分子。其中许多 lncRNA 作为重要的转录和转录后调控因子，影响基因表达，并靶向其他调节分子，如 miRNAs。由于它们对 Notch 相关分子的功能和基因表达有很强的影响，lncRNA 影响癌症和其他疾病的易感性，可以被视为潜在的生物标志物和治疗靶点。在这一章中，我们总结了 Notch 信号通路及其最重要的调节 lncRNA 之间的相互作用，以及这些相互作用在不同组织中的病理后果。
