Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; Research Unit of Non-Coding RNA and Genome Editing in Cancer, Medical University of Graz, 8036 Graz, Austria; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; Research Unit of Non-Coding RNA and Genome Editing in Cancer, Medical University of Graz, 8036 Graz, Austria.
Cancer Lett. 2018 Apr 28;420:91-96. doi: 10.1016/j.canlet.2018.01.070. Epub 2018 Feb 2.
The Notch signaling pathway has a key role in cellular development and is involved in initiation and progression of cancer by fundamentally influencing cellular processes such as differentiation, proliferation or migration. The pathway is regulated on many stages, generating diverse outcomes depending on cellular context or signaling dose. Recent studies suggest that long non-coding RNAs (lncRNAs), a class of non-coding RNAs deregulated in many cancers, are involved in regulating the Notch pathway activity by modulating the expression of receptors or ligands on transcriptional or posttranscriptional levels. LncRNAs are also downstream targets of Notch signaling and some of these Notch-induced lncRNAs have been reported to be inducers of its oncogenic effects. This cross-talk between Notch signaling and lncRNAs makes those molecules potential biomarkers for Notch signaling activity and interesting therapeutic RNA-based targets in the future.
Notch 信号通路在细胞发育中起着关键作用，通过从根本上影响细胞分化、增殖或迁移等过程，参与癌症的发生和进展。该通路在多个阶段受到调控，根据细胞环境或信号剂量的不同，产生不同的结果。最近的研究表明，长链非编码 RNA（lncRNA）是一类在许多癌症中失调的非编码 RNA，通过调节转录或转录后水平上受体或配体的表达，参与调控 Notch 通路活性。lncRNA 也是 Notch 信号的下游靶标，一些 Notch 诱导的 lncRNA 已被报道为其致癌效应的诱导剂。Notch 信号和 lncRNA 之间的这种串扰使得这些分子成为 Notch 信号活性的潜在生物标志物，并成为未来基于 RNA 的有前途的治疗靶点。
