Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Translational Neuro-Oncology Laboratory, San Diego (UCSD) Moores Cancer Center, University of California, CA, United States.
Biomed Pharmacother. 2021 Jun;138:111496. doi: 10.1016/j.biopha.2021.111496. Epub 2021 Mar 17.
Notch pathway is a signaling cascade with important impacts on cell proliferation, differentiation, developmental processes and tissue homeostasis. This pathway also regulates stem cell properties, thus being involved in both normal developmental processes and metastatic capacity of cancer cells. Lots of lncRNAs and miRNAs have been recognized that control Notch pathway at some levels or their expression is regulated by this pathway. FOXD2-AS1, MEG3, ANRIL, linc-OIP5, lincRNA-p21, CBR3-AS1, HOTAIR, PVT1 and GAS5 are among lncRNAs that interact with Notch signaling. miR-19, miR-21, miR-33a, miR-8/200, miR-34a, miR-146a, miR-37, miR-100, miR-107 and several other miRNAs have functional interplay with this signaling cascade. In the present review article, we have illuminated the interplay between lncRNAs/miRNAs and Notch pathway in two distinct contexts i.e. cancers and non-neoplastic conditions.
Notch 通路是一条信号级联，对细胞增殖、分化、发育过程和组织平衡有重要影响。该通路还调节干细胞特性，因此参与正常发育过程和癌细胞的转移能力。已经识别出许多 lncRNA 和 miRNA，它们在某些水平上控制 Notch 通路，或者它们的表达受该通路调节。FOXD2-AS1、MEG3、ANRIL、linc-OIP5、lncRNA-p21、CBR3-AS1、HOTAIR、PVT1 和 GAS5 是与 Notch 信号相互作用的 lncRNA 之一。miR-19、miR-21、miR-33a、miR-8/200、miR-34a、miR-146a、miR-37、miR-100、miR-107 和其他几种 miRNA 与该信号级联具有功能相互作用。在本文综述中，我们阐明了 lncRNA/miRNA 与癌症和非肿瘤性疾病两种不同情况下 Notch 通路之间的相互作用。
