DSM Nutritional Products, Kaiseraugst, Switzerland.
DSM Nutritional Products, Columbia, MD, USA.
J Anim Physiol Anim Nutr (Berl). 2020 Sep;104(5):1509-1523. doi: 10.1111/jpn.13324. Epub 2020 Feb 18.
Algal Oil Containing EPA and DHA (AOCED) at approximately 50% was developed as a sustainable n-3 fatty acid source. AOCED was incorporated in diets at dose levels of 0%, 0.75%, 1.5% and 3.0% (w/w) and administered to healthy domestic shorthair female cats starting two weeks before mating, then during mating, gestation, lactation and to their kittens until they reached 32 weeks of age. The diets were made isocaloric and met the Association of American Feed Control Officials (AAFCO) nutrient requirements of cats for growth and reproduction. Dietary AOCED treatment did not affect the overall health, physiological parameters, food consumption and body weights of the queens and their kittens. No AOCED-related changes in haematology, coagulation or clinical chemistry parameters were observed in either generation when compared to control cats. Plasma levels of EPA and DHA were dose-dependently increased in both generations, demonstrating bioavailability of the fatty acids. In this study, safety of AOCED at levels up to 3.0% in the diet was demonstrated in cats with administration starting in utero and until kittens reached 32 weeks of age. Bioavailability of EPA and DHA in cats supports use of AOCED as a source of EPA and DHA for feline growth and reproduction.
开发含有 EPA 和 DHA（AOCED）约 50%的藻类油作为可持续的 n-3 脂肪酸来源。AOCED 以 0%、0.75%、1.5%和 3.0%（w/w）的剂量水平掺入饮食中，从交配前两周开始，在交配期间、妊娠期间、哺乳期和小猫达到 32 周龄时，给健康的家养短毛雌猫喂食。这些饮食是等热量的，并满足美国饲料控制官员协会（AAFCO）猫的生长和繁殖的营养需求。饮食 AOCED 处理不会影响母猫及其小猫的整体健康、生理参数、食物消耗和体重。与对照组猫相比，在任何一代中，都没有观察到与 AOCED 相关的血液学、凝血或临床化学参数的变化。在两代中，EPA 和 DHA 的血浆水平都呈剂量依赖性增加，表明脂肪酸的生物利用度。在这项研究中，在饮食中添加高达 3.0%的 AOCED 在猫中是安全的，从子宫内开始给药，直到小猫达到 32 周龄。猫中 EPA 和 DHA 的生物利用度支持使用 AOCED 作为 EPA 和 DHA 的来源，用于猫的生长和繁殖。
