UCL Institute of Ophthalmology, University College London, London, UK.
Department of Biomedical Engineering, Wayne State University, Detroit, Michigan.
J Biophotonics. 2020 May;13(5):e201960097. doi: 10.1002/jbio.201960097. Epub 2020 Feb 26.
Optical coherence tomography (OCT), with a high-spatial resolution (<10 microns), intermediate penetration depth (~1.5 mm) and volumetric imaging capability is a great candidate to be used as a diagnostic-assistant modality in dermatology. At this time, the accuracy of OCT for melanoma detection is lower than anticipated. In this letter, we studied for the first time, the use of a novel contrast agent consist of ultra-small nanoparticles conjugated to a melanoma biomarker to improve the accuracy of OCT for differentiation of melanoma cells from nonmelanoma cells, in vitro. We call this approach SMall nanoparticle Aggregation-enhanced Radiomics of Tumor (SMART)-OCT imaging. This initial proof of concept study is the first step toward the broad utilization of this method for high accuracy all types of tumor detection applications.
光学相干断层扫描（OCT）具有高空间分辨率（<10 微米）、中等穿透深度（~1.5 毫米）和体积成像能力，是皮肤科诊断辅助手段的理想选择。目前，OCT 检测黑色素瘤的准确性低于预期。在本研究中，我们首次研究了使用一种新型造影剂，该造影剂由与黑色素瘤生物标志物偶联的超小纳米颗粒组成，以提高 OCT 对黑色素瘤细胞与非黑色素瘤细胞的体外区分的准确性。我们将这种方法称为小纳米颗粒增强肿瘤放射组学（SMART）-OCT 成像。这项初步的概念验证研究是广泛应用该方法进行高精度肿瘤检测的第一步。
