玻璃体内注射环孢素的视网膜毒性研究
Retinal toxicity study of intravitreal cyclosporin.
作者信息
Grisolano J, Peyman G A
出版信息
Ophthalmic Surg. 1986 Mar;17(3):155-6.
PMID:3960475
Abstract
We investigated the toxicity of intravitreal cyclosporin in the rabbit. Histologic retinal changes were found with intravitreal injections of 200 micrograms. No histologic or electroretinographic changes were observed with doses of 100 micrograms or less. This nontoxic dose is projected to be at least 77 times the amount needed to be effective.
摘要
我们研究了玻璃体内注射环孢菌素对家兔的毒性。玻璃体内注射200微克时发现有视网膜组织学变化。注射100微克或更低剂量时未观察到组织学或视网膜电图变化。预计这一无毒剂量至少是有效所需剂量的77倍。
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