Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Division of Regenerative Medicine, School of Medicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
Lab Med. 2020 Sep 1;51(5):519-528. doi: 10.1093/labmed/lmaa002.
This study assessed the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume, platelet distribution width, and red cell distribution width (RDW) in systemic lupus erythematosus (SLE) patients and their correlation with disease activity.
Two hundred eight SLE patients and 205 age- and sex-matched healthy controls were included. Disease activity was assessed using the systemic lupus erythematosus disease activity index 2000, and hematological indices were determined.
Lymphocyte and platelet counts were significantly lower in SLE patients than in the controls, while the NLR, PLR, and RDW were significantly higher (P < .05). In patients with active disease, the neutrophil counts, NLR, and PLR were significantly higher than in those with inactive disease (P < .05), while the lymphocyte count was significantly lower (P < .05). Based on receiver operating characteristic curve analyses, only for lymphocyte count and PLR. The area under curve was significantly higher (P = .001 and P = .053, respectively).
PLR can serve as a biomarker for indicating SLE disease activity.
本研究评估了系统性红斑狼疮（SLE）患者中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、平均血小板体积、血小板分布宽度和红细胞分布宽度（RDW），并分析其与疾病活动度的相关性。
共纳入 208 例 SLE 患者和 205 例年龄和性别匹配的健康对照者。采用系统性红斑狼疮疾病活动指数 2000 评估疾病活动度，检测血液学指标。
SLE 患者的淋巴细胞和血小板计数明显低于对照组，而 NLR、PLR 和 RDW 明显高于对照组（P<0.05）。在活动期患者中，中性粒细胞计数、NLR 和 PLR 明显高于非活动期患者（P<0.05），而淋巴细胞计数明显降低（P<0.05）。基于受试者工作特征曲线分析，仅淋巴细胞计数和 PLR 的曲线下面积显著较高（P=0.001 和 P=0.053）。
PLR 可作为提示 SLE 疾病活动度的生物标志物。
