发展中国家甲状腺毒症的术前治疗：卡比马唑与普萘洛尔的对比研究
Preoperative treatment of thyrotoxicosis in developing countries: a comparative study of carbimazole and propranolol.
作者信息
Haddad J F, Tibblin S
机构信息
Department of Surgery, Mubarak Al Kabir Hospital, Kuwait.
出版信息
Ann R Coll Surg Engl. 1988 Nov;70(6):357-60.
Preoperative management of treatment in thyrotoxicosis was investigated in a comparative study of carbimazole and propranolol in 41 consecutive patients collected during a 3-year period. The groups included 20 and 21 patients respectively, of equal sex and age distribution and of similar severity. The length of the preoperative treatment was significantly reduced in the propranolol pretreated patients (P greater than 0.001). Intraoperative blood loss, postoperative function with regard to the thyroid, parathyroids and vocal cords were similar in both groups. Three and two patients respectively had permanent hypothyroidism requiring thyroxin treatment. In patients with therapy compliance problems treatment with propranolol would entail a definite advantage, particularly in developing countries.
在一项为期3年的研究中，对41例连续患者进行了卡比马唑和普萘洛尔的对比研究，以探讨甲状腺毒症术前治疗的管理。两组分别有20例和21例患者，性别和年龄分布相同，病情严重程度相似。普萘洛尔预处理患者的术前治疗时间显著缩短（P>0.001）。两组的术中出血量、甲状腺、甲状旁腺和声带的术后功能相似。分别有3例和2例患者出现永久性甲状腺功能减退，需要甲状腺素治疗。对于治疗依从性有问题的患者，使用普萘洛尔治疗具有明显优势，尤其是在发展中国家。
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