抗II型和XI型胶原蛋白抗体：类风湿性关节炎患者体内抗原特异性及交叉反应性抗体形成的证据。
Antibodies to type II and XI collagens: evidence for the formation of antigen specific as well as cross reacting antibodies in patients with rheumatoid arthritis.
作者信息
Morgan K, Buckee C, Collins I, Ayad S, Clague R B, Holt P J
机构信息
Department of Rheumatology, University of Manchester Medical School.
出版信息
Ann Rheum Dis. 1988 Dec;47(12):1008-13. doi: 10.1136/ard.47.12.1008.
Antigen specific and cross reacting antibodies to native and denatured types II and XI collagen were detected in the sera of rats immunised with either of these antigens. The antibodies from rats immunised with type XI collagen initially showed the strongest binding to the alpha 2(XI) chain of type XI collagen but later binding to the alpha 3(XI) chain was seen. Sera from patients with rheumatoid arthritis had antibodies that bound to both type II and XI collagens. Immunoblotting studies showed that most patients had antibodies which bound to the alpha 1(II) chain of type II collagen and to the alpha 3(XI) chain of type XI collagen. Some patients also had antibodies which bound to the alpha 1(XI) and to the alpha 2(XI) chains of type XI collagen. Thus antibodies to unique as well as to common epitopes on each of the two types of collagen molecule occur in some patients with rheumatoid arthritis.
在用这两种抗原之一免疫的大鼠血清中，检测到了针对天然和变性II型及XI型胶原蛋白的抗原特异性和交叉反应性抗体。用XI型胶原蛋白免疫的大鼠产生的抗体最初对XI型胶原蛋白的α2(XI)链显示出最强的结合，但后来也出现了与α3(XI)链的结合。类风湿性关节炎患者的血清中有与II型和XI型胶原蛋白都结合的抗体。免疫印迹研究表明，大多数患者的抗体与II型胶原蛋白的α1(II)链和XI型胶原蛋白的α3(XI)链结合。一些患者还具有与XI型胶原蛋白的α1(XI)链和α2(XI)链结合的抗体。因此，在一些类风湿性关节炎患者中，存在针对这两种胶原蛋白分子各自独特及共同表位的抗体。
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