Morgan K, Clague R B, Collins I, Ayad S, Phinn S D, Holt P J
Department of Rheumatology, University of Manchester Medical School.
Ann Rheum Dis. 1987 Dec;46(12):902-7. doi: 10.1136/ard.46.12.902.
The frequencies of antibodies to the cartilage type IX and XI collagens and to type I collagen were determined in 188 patients with rheumatoid arthritis, of whom 76 were positive for antibodies to native type II collagen. A higher proportion of patients with antibodies to native type II collagen had antibodies to these other collagens, but about one third of patients without antibodies to native type II collagen had antibodies to one or more denatured collagens. The patterns of antibodies present in individual sera suggested that there was a selective response to the collagens in an individual patient. The incidence of patients having antibodies to these native and denatured collagens in a random group of patients with rheumatoid arthritis was calculated.
在188例类风湿性关节炎患者中测定了针对软骨IX型和XI型胶原蛋白以及I型胶原蛋白的抗体频率，其中76例针对天然II型胶原蛋白的抗体呈阳性。针对天然II型胶原蛋白的抗体阳性患者中，有更高比例的患者针对这些其他胶原蛋白也有抗体，但约三分之一未针对天然II型胶原蛋白产生抗体的患者针对一种或多种变性胶原蛋白产生了抗体。个体血清中存在的抗体模式表明，个体患者对胶原蛋白存在选择性反应。计算了一组随机的类风湿性关节炎患者中针对这些天然和变性胶原蛋白产生抗体的患者发生率。
