The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Yunnan Provincial Center for Disease Control and Prevention, 158 Dongsi street, Kunming, Yunnan, 650022, People's Republic of China.
BMC Infect Dis. 2020 Feb 19;20(1):154. doi: 10.1186/s12879-020-4858-6.
The emergence of human infection with avian influenza A(H7N9) virus was reported in Wenshan City, southwestern China in 2017. The study describes the epidemiological and virological features of the outbreak and discusses the origin of the infection.
Poultry exposure and timelines of key events for each patient were collected. Samples derived from the patients, their close contacts, and environments were tested for influenza A(H7N9) virus by real-time reverse transcription polymerase chain reaction. Genetic sequencing and phylogenetic analysis were also conducted.
Five patients were reported in the outbreak. An epidemiological investigation showed that all patients had been exposed at live poultry markets. The A(H7N9) isolates from these patients had low pathogenicity in avian species. Both epidemiological investigations of chicken sources and phylogenetic analysis of viral gene sequences indicated that the source of infection was from Guangxi Province, which lies 100 km to the east of Wenshan City.
In the study, a sudden emergence of human cases of H7N9 was documented in urban area of Wenshan City. Chickens were an important carrier in the H7N9 virus spreading from Guangxi to Wenshan. Hygienic management of live poultry markets and virological screening of chickens transported across regions should be reinforced to limit the spread of H7N9 virus.
2017 年中国西南部文山州报告了人感染甲型禽流感（H7N9）病毒。本研究描述了疫情的流行病学和病毒学特征，并讨论了感染的起源。
收集了每位患者的禽类接触史和关键事件时间线。通过实时逆转录聚合酶链反应检测来自患者、密切接触者和环境的样本中的甲型禽流感（H7N9）病毒。还进行了遗传测序和系统进化分析。
疫情中报告了 5 例病例。流行病学调查显示，所有患者均在活禽市场暴露过。这些患者的 A(H7N9)分离株对禽类具有低致病性。对鸡源的流行病学调查和病毒基因序列的系统进化分析均表明，感染源来自 100 公里以东的广西壮族自治区。
本研究记录了文山市区突然出现人感染 H7N9 病例。鸡是 H7N9 病毒从广西传播到文山的重要载体。应加强活禽市场的卫生管理和跨地区运输鸡的病毒学筛查，以限制 H7N9 病毒的传播。
