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Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate.蛋白质组整体可溶性改变高通量蛋白质组学测定鉴定 Collectin-12 为非凋亡性小胶质细胞半胱氨酸蛋白酶-3 的底物。
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A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.益生元饮食可调节过表达α-突触核蛋白小鼠的小胶质细胞状态和运动缺陷。
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本文引用的文献

1
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.补体 C3 在人类 AD 脑中被激活，并在淀粉样变性和 Tau 病的小鼠模型中导致神经退行性变。
Cell Rep. 2019 Aug 20;28(8):2111-2123.e6. doi: 10.1016/j.celrep.2019.07.060.
2
Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance.神经炎症与阿尔茨海默病的功能连接：对认知表现的交互影响。
J Neurosci. 2019 Sep 4;39(36):7218-7226. doi: 10.1523/JNEUROSCI.2574-18.2019. Epub 2019 Jul 18.
3
Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response.神经疾病中的小胶质细胞：脑疾病依赖性炎症反应路线图
Front Cell Neurosci. 2018 Dec 18;12:488. doi: 10.3389/fncel.2018.00488. eCollection 2018.
4
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.TREM2 功能丧失会增加淀粉样蛋白的形成，但会减少斑块相关的载脂蛋白 E。
Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7.
5
New insights into the role of TREM2 in Alzheimer's disease.对 TREM2 在阿尔茨海默病中的作用的新认识。
Mol Neurodegener. 2018 Dec 20;13(1):66. doi: 10.1186/s13024-018-0298-9.
6
Neuroinflammation in mouse models of Alzheimer's disease.阿尔茨海默病小鼠模型中的神经炎症
Clin Exp Neuroimmunol. 2018 Nov;9(4):211-218. doi: 10.1111/cen3.12475. Epub 2018 Sep 23.
7
[C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.阿尔茨海默病和进行性核上性麻痹中 PK11195 的结合。
Neurology. 2018 May 29;90(22):e1989-e1996. doi: 10.1212/WNL.0000000000005610. Epub 2018 Apr 27.
8
Normal aging induces A1-like astrocyte reactivity.正常衰老会引起 A1 样星形胶质细胞反应。
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1896-E1905. doi: 10.1073/pnas.1800165115. Epub 2018 Feb 7.
9
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.TREM2 缺乏可减轻神经炎症并预防神经退行性变tau 病模型中的小鼠。
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11524-11529. doi: 10.1073/pnas.1710311114. Epub 2017 Oct 9.
10
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.TREM2 缺乏通过调节激酶信号通路加剧 tau 病理改变，在 tau 病小鼠模型中。
Mol Neurodegener. 2017 Oct 16;12(1):74. doi: 10.1186/s13024-017-0216-6.

The Dual Role of Microglia in the Progression of Alzheimer's Disease.

作者信息

Onuska Kate M

机构信息

Graduate Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, Ontario N6A 5C1, Canada

出版信息

J Neurosci. 2020 Feb 19;40(8):1608-1610. doi: 10.1523/JNEUROSCI.2594-19.2020.

DOI:10.1523/JNEUROSCI.2594-19.2020
PMID:32075949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7046328/
Abstract
摘要