相似文献
1
The Dual Role of Microglia in the Progression of Alzheimer's Disease.小胶质细胞在阿尔茨海默病进展中的双重作用
J Neurosci. 2020 Feb 19;40(8):1608-1610. doi: 10.1523/JNEUROSCI.2594-19.2020.
2
Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression.动态小胶质细胞改变与海马网络损伤相关：淀粉样蛋白病理进展的转折点。
Brain Behav Immun. 2024 Jul;119:286-300. doi: 10.1016/j.bbi.2024.04.009. Epub 2024 Apr 10.
3
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models.纤维状 Aβ 在阿尔茨海默病小鼠模型中引发小胶质细胞蛋白质组改变和功能障碍。
Elife. 2020 Jun 8;9:e54083. doi: 10.7554/eLife.54083.
4
Exploring the link between dystrophic microglia and the spread of Alzheimer's neuropathology.探索营养不良性小胶质细胞与阿尔茨海默病神经病理学传播之间的联系。
Brain. 2025 Jan 7;148(1):89-101. doi: 10.1093/brain/awae258.
5
Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.在阿尔茨海默病小鼠中清除小胶质细胞可预防神经元丢失，而不调节淀粉样β蛋白病变。
Brain. 2016 Apr;139(Pt 4):1265-81. doi: 10.1093/brain/aww016. Epub 2016 Feb 26.
6
Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice.淀粉样斑块进展过程中活化小胶质细胞中环氧化酶-1的检测：阿尔茨海默病模型小鼠的正电子发射断层扫描研究
J Nucl Med. 2016 Feb;57(2):291-6. doi: 10.2967/jnumed.115.166116. Epub 2015 Nov 19.
7
Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model.TSPO PET 测量的小胶质细胞与阿尔茨海默病病理有关，并介导疾病进展模型中的关键步骤。
Alzheimers Dement. 2024 Apr;20(4):2397-2407. doi: 10.1002/alz.13699. Epub 2024 Feb 1.
8
Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease.匹兹堡化合物 B 正电子发射断层扫描首位阿尔茨海默病患者的正电子发射断层扫描影像与分子病理学及临床进展的关系。
Brain. 2011 Jan;134(Pt 1):301-17. doi: 10.1093/brain/awq349. Epub 2010 Dec 13.
9
Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis.小胶质细胞受体及其在淀粉样β对阿尔茨海默病发病机制反应中的意义。
J Neuroinflammation. 2014 Mar 13;11:48. doi: 10.1186/1742-2094-11-48.
10
Nogo receptor impairs the clearance of fibril amyloid-β by microglia and accelerates Alzheimer's-like disease progression.神经生长抑制因子受体抑制小胶质细胞对纤维状淀粉样β的清除，并加速类似阿尔茨海默病的疾病进展。
Aging Cell. 2021 Dec;20(12):e13515. doi: 10.1111/acel.13515. Epub 2021 Nov 24.
引用本文的文献
1
Progression Independent of the Triggering Event in Neurologic Diseases.神经系统疾病中与触发事件无关的进展
Neurol Neuroimmunol Neuroinflamm. 2025 Sep;12(5):e200447. doi: 10.1212/NXI.0000000000200447. Epub 2025 Jul 16.
2
The dual role of microglia in Alzheimer's disease: from immune regulation to pathological progression.小胶质细胞在阿尔茨海默病中的双重作用：从免疫调节到病理进展。
Front Aging Neurosci. 2025 Mar 27;17:1554398. doi: 10.3389/fnagi.2025.1554398. eCollection 2025.
3
Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation.抑制转化生长因子-β信号通路对β-淀粉样蛋白诱导的直接神经毒性和小胶质细胞介导的神经炎症具有神经保护作用。
Neurol Res Int. 2025 Jan 30;2025:8948290. doi: 10.1155/nri/8948290. eCollection 2025.
4
Immune mechanisms and shared immune targets in neurodegenerative diseases.神经退行性疾病中的免疫机制和共同免疫靶点
Nat Rev Neurol. 2025 Feb;21(2):67-85. doi: 10.1038/s41582-024-01046-7. Epub 2024 Dec 16.
5
Cell States and Interactions of CD8 T Cells and Disease-Enriched Microglia in Human Brains with Alzheimer's Disease.阿尔茨海默病患者大脑中CD8 T细胞与疾病富集小胶质细胞的细胞状态及相互作用
Biomedicines. 2024 Jan 29;12(2):308. doi: 10.3390/biomedicines12020308.
6
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer's brains.在衰老和 APOE4 基因型阿尔茨海默病大脑中，积累了一种疲惫样的小胶质细胞群体。
Immunity. 2024 Jan 9;57(1):153-170.e6. doi: 10.1016/j.immuni.2023.12.001. Epub 2023 Dec 29.
7
Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential.肌萎缩侧索硬化症中的小胶质细胞和星形胶质细胞：疾病相关状态、病理作用及治疗潜力
Biology (Basel). 2023 Oct 3;12(10):1307. doi: 10.3390/biology12101307.
8
Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate.蛋白质组整体可溶性改变高通量蛋白质组学测定鉴定 Collectin-12 为非凋亡性小胶质细胞半胱氨酸蛋白酶-3 的底物。
Cell Death Dis. 2023 Mar 11;14(3):192. doi: 10.1038/s41419-023-05714-2.
9
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.益生元饮食可调节过表达α-突触核蛋白小鼠的小胶质细胞状态和运动缺陷。
Elife. 2022 Nov 8;11:e81453. doi: 10.7554/eLife.81453.
10
Therapeutic potential for P2Y receptor antagonism.P2Y 受体拮抗作用的治疗潜力。
Purinergic Signal. 2023 Jun;19(2):401-420. doi: 10.1007/s11302-022-09900-3. Epub 2022 Oct 11.
本文引用的文献
1
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.补体 C3 在人类 AD 脑中被激活，并在淀粉样变性和 Tau 病的小鼠模型中导致神经退行性变。
Cell Rep. 2019 Aug 20;28(8):2111-2123.e6. doi: 10.1016/j.celrep.2019.07.060.
2
Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance.神经炎症与阿尔茨海默病的功能连接：对认知表现的交互影响。
J Neurosci. 2019 Sep 4;39(36):7218-7226. doi: 10.1523/JNEUROSCI.2574-18.2019. Epub 2019 Jul 18.
3
Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response.神经疾病中的小胶质细胞：脑疾病依赖性炎症反应路线图
Front Cell Neurosci. 2018 Dec 18;12:488. doi: 10.3389/fncel.2018.00488. eCollection 2018.
4
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.TREM2 功能丧失会增加淀粉样蛋白的形成，但会减少斑块相关的载脂蛋白 E。
Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7.
5
New insights into the role of TREM2 in Alzheimer's disease.对 TREM2 在阿尔茨海默病中的作用的新认识。
Mol Neurodegener. 2018 Dec 20;13(1):66. doi: 10.1186/s13024-018-0298-9.
6
Neuroinflammation in mouse models of Alzheimer's disease.阿尔茨海默病小鼠模型中的神经炎症
Clin Exp Neuroimmunol. 2018 Nov;9(4):211-218. doi: 10.1111/cen3.12475. Epub 2018 Sep 23.
7
[C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.阿尔茨海默病和进行性核上性麻痹中 PK11195 的结合。
Neurology. 2018 May 29;90(22):e1989-e1996. doi: 10.1212/WNL.0000000000005610. Epub 2018 Apr 27.
8
Normal aging induces A1-like astrocyte reactivity.正常衰老会引起 A1 样星形胶质细胞反应。
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1896-E1905. doi: 10.1073/pnas.1800165115. Epub 2018 Feb 7.
9
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.TREM2 缺乏可减轻神经炎症并预防神经退行性变tau 病模型中的小鼠。
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11524-11529. doi: 10.1073/pnas.1710311114. Epub 2017 Oct 9.
10
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.TREM2 缺乏通过调节激酶信号通路加剧 tau 病理改变，在 tau 病小鼠模型中。
Mol Neurodegener. 2017 Oct 16;12(1):74. doi: 10.1186/s13024-017-0216-6.
Zotero 插件