Sainsbury J R, Nicholson S, Angus B, Farndon J R, Malcolm A J, Harris A L
Department of Surgery, University of Newcastle upon Tyne, UK.
Br J Cancer. 1988 Oct;58(4):458-60. doi: 10.1038/bjc.1988.240.
The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptors have all recurred within two years of resection. Twenty-one percent of the lobular carcinomas contained EGF receptors compared to 34% of ductal carcinomas. EGF receptor status appeared to be associated with an increased risk of early recurrence and death whatever the histological sub-type of the breast cancer.
对连续264例手术切除的乳腺恶性病变进行了组织学分析。对雌激素和表皮生长因子受体状态进行了量化，并与非导管性病变的大小和淋巴结状态一起呈现。那些含有表皮生长因子受体的非导管性肿瘤在切除后两年内均复发。21%的小叶癌含有表皮生长因子受体，而导管癌为34%。无论乳腺癌的组织学亚型如何，表皮生长因子受体状态似乎都与早期复发和死亡风险增加有关。
