Kokoro Research Center, Kyoto University, Kyoto University, 46 Shimoadachi, Sakyo, Kyoto, 606-8501, Japan.
Brain Activity Imaging Center, ATR-Promotions, 2-2-2 Hikaridai, Seika-cho, Soraku-gun, Kyoto, 619-0288, Japan.
Sci Rep. 2020 Feb 19;10(1):2951. doi: 10.1038/s41598-020-59758-x.
Perceived social support enhances well-being and prevents stress-related ill-being. A recent structural neuroimaging study reported that the amygdala volume is positively associated with perceived social support. However, it remains unknown how neural activity in this region and functional connectivity (FC) between this and other regions are related to perceived social support. To investigate these issues, resting-state functional magnetic resonance imaging was performed to analyze the fractional amplitude of low-frequency fluctuation (fALFF). Perceived social support was evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS). Lower fALFF values in the bilateral amygdalae were associated with higher MSPSS scores. Additionally, stronger FC between the left amygdala and right orbitofrontal cortex and between the left amygdala and bilateral precuneus were associated with higher MSPSS scores. The present findings suggest that reduced amygdala activity and heightened connectivity between the amygdala and other regions underlie perceived social support and its positive functions.
感知到的社会支持可以增强幸福感，预防与压力相关的不适。最近的一项结构神经影像学研究报告称，杏仁核体积与感知到的社会支持呈正相关。然而，目前尚不清楚该区域的神经活动以及该区域与其他区域之间的功能连接（FC）与感知到的社会支持有何关系。为了研究这些问题，进行了静息态功能磁共振成像以分析低频波动的分数幅度（fALFF）。使用多维感知社会支持量表（MSPSS）评估感知到的社会支持。双侧杏仁核的 fALFF 值越低，MSPSS 得分越高。此外，左杏仁核与右眶额皮质之间以及左杏仁核与双侧楔前叶之间的 FC 越强，MSPSS 得分越高。本研究结果表明，杏仁核活动减少和杏仁核与其他区域之间的连接增强是感知到的社会支持及其积极功能的基础。
