Department of Medical Genetics, Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou 213003, China.
Dis Markers. 2020 Jan 28;2020:1805764. doi: 10.1155/2020/1805764. eCollection 2020.
The association between tumour-infiltrating immune cells and the prognosis of endometrial cancer (EC) is controversial due to the smaller sample sizes and limited statistical power of the extant studies. We carried out a meta-analysis of the relationship between tumour-infiltrating immune cells and EC survival outcomes.
A literature search in multiple databases was carried out up to December 2019. Pooled hazard ratio (HRs) and 95% confidence intervals (CIs) were calculated by the -test to assess the association between infiltrating immune cells and overall survival (OS), progression-free survival (PFS), relapse-free survival (RFS), disease-specific survival (DSS), and disease-free survival (DFS). A subgroup analysis was performed based on the localisation of immune cells in tumour parenchyma or stroma, immune markers, and the International Federation of Gynecology and Obstetrics stage. Heterogeneity and publication bias between studies were evaluated by Cochran's -test and Egger regression test, respectively.
Seventeen studies were included in the analysis. The pooled HR of OS, PFS, DSS, and DFS indicated that a high CD8 T cell density was associated with a favorable prognosis in EC patients. A significant relationship was found between a high density of CD45RO T cells and a favorable OS in EC patients, but the FoxP3 T cell density was not associated with either OS or RFS. A high TAM density was associated with a worse PFS. However, a sensitivity analysis indicated that the findings of PFS and DSS in CD8 T cell and PFS in TAM were not robust results.
This is the first meta-analysis of the relationship between tumour-infiltrating immune cells and the prognosis of EC. High CD8 and CD45RO T cell densities in tumours were associated with favorable outcomes in EC patients.
由于现有研究的样本量较小且统计效力有限，肿瘤浸润免疫细胞与子宫内膜癌（EC）预后之间的关联存在争议。我们对肿瘤浸润免疫细胞与 EC 生存结局之间的关系进行了荟萃分析。
对多个数据库进行了文献检索，检索时间截至 2019 年 12 月。通过 -检验计算合并风险比（HR）和 95%置信区间（CI），以评估浸润免疫细胞与总生存（OS）、无进展生存（PFS）、无复发生存（RFS）、疾病特异性生存（DSS）和无病生存（DFS）之间的关系。根据免疫细胞在肿瘤实质或基质中的定位、免疫标志物和国际妇产科联合会（FIGO）分期进行亚组分析。通过 Cochran's -检验和 Egger 回归检验分别评估研究之间的异质性和发表偏倚。
纳入了 17 项研究进行分析。OS、PFS、DSS 和 DFS 的合并 HR 表明，EC 患者中 CD8 T 细胞密度高与预后良好相关。在 EC 患者中，CD45RO T 细胞密度高与 OS 良好相关，但 FoxP3 T 细胞密度与 OS 或 RFS 均无关。TAM 密度高与 PFS 较差相关。然而，敏感性分析表明，CD8 T 细胞的 PFS 和 DSS 以及 TAM 的 PFS 发现结果并不稳健。
这是首次对肿瘤浸润免疫细胞与 EC 预后之间的关系进行的荟萃分析。肿瘤中高 CD8 和 CD45RO T 细胞密度与 EC 患者的良好结局相关。
