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药物,包括酒精,可作为白内障的危险因素,以及阿司匹林样镇痛药和环戊噻嗪对白内障可能具有的保护作用。

Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide.

作者信息

Harding J J, van Heyningen R

机构信息

Nuffield Laboratory of Ophthalmology, University of Oxford.

出版信息

Br J Ophthalmol. 1988 Nov;72(11):809-14. doi: 10.1136/bjo.72.11.809.

Abstract

A case-control study of cataract in Oxfordshire explored the risks and benefits associated with a variety of drugs. Steroids including the diuretic spironolactone, nifedipine, heavy smoking, and beer drinking were associated with a raised risk. On the other hand aspirin-like analgesics (paracetamol, ibuprofen, aspirin, etc. appeared to protect against cataract. Cyclopenthiazide appeared to provide a similar protection.

摘要

牛津郡一项关于白内障的病例对照研究探讨了多种药物相关的风险和益处。包括利尿剂螺内酯、硝苯地平在内的类固醇、大量吸烟和饮用啤酒与风险升高相关。另一方面,类阿司匹林镇痛药(对乙酰氨基酚、布洛芬、阿司匹林等)似乎可预防白内障。环戊噻嗪似乎也有类似的预防作用。

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Do aspirin-like analgesics protect against cataract? A case-control study.
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Can drugs or micronutrients prevent cataract?药物或微量营养素能预防白内障吗?
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本文引用的文献

1
DIABETIC RETINOPATHY AND RHEUMATOID ARTHRITIS.糖尿病性视网膜病变与类风湿关节炎。
Lancet. 1964 Jul 4;2(7349):17-8. doi: 10.1016/s0140-6736(64)90008-x.
3
Aspirin and diabetes mellitus.阿司匹林与糖尿病
Br Med J. 1957 Nov 9;2(5053):1071-4. doi: 10.1136/bmj.2.5053.1071.
4
Analysis of individual cataract patients and their lenses: a progress report.
Exp Eye Res. 1980 Nov;31(5):553-66. doi: 10.1016/s0014-4835(80)80014-5.
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Some risk factors associated with cataract in S.E. Scotland: a pilot study.
Trans Ophthalmol Soc U K (1962). 1982;102 Pt 3:331-6.
7
Distribution of salicylate in lens and intraocular fluids and its effect on cataract formation.
Am J Med. 1983 Jun 14;74(6A):83-90. doi: 10.1016/0002-9343(83)90534-x.
10

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