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锶/壳聚糖/羟基磷灰石/去甲斑蝥素复合材料体外抑制骨肉瘤并促进成骨。

Strontium/Chitosan/Hydroxyapatite/Norcantharidin Composite That Inhibits Osteosarcoma and Promotes Osteogenesis In Vitro.

机构信息

The First Affiliated Hospital of Harbin Medical University, No. 23 Post Street, Nangang District, Harbin, Heilongjiang, China.

出版信息

Biomed Res Int. 2020 Jan 30;2020:9825073. doi: 10.1155/2020/9825073. eCollection 2020.

DOI:10.1155/2020/9825073
PMID:32076624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7013326/
Abstract

Hydroxyapatite can deliver drugs, and its composite material is capable of repairing bone defects in tumors. This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction. Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR). In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied. The use of nano-SHAP alone did not affect the proliferation of normal cell lines. However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts. And, with the increase of the content of norcantharidin, the antitumor performance of the composite has been enhanced. In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.

摘要

羟基磷灰石可以递送药物，其复合材料能够修复肿瘤中的骨缺损。本研究旨在评估复合材料对肿瘤生长抑制和骨生长诱导的效果。通过共沉淀和冷冻干燥合成了含有药物输送化合物的复合材料，并通过扫描电子显微镜 (SEM)、X 射线衍射 (XRD) 和傅里叶变换红外光谱 (FTIR) 进行了表征。此外，还评估了羟基磷灰石纳米粒子 (nano-SHAP) 对骨肉瘤细胞系 (MG-63) 和成骨细胞系 (MC3T3-E1) 增殖的影响，并研究了其作用机制。单独使用 nano-SHAP 不会影响正常细胞系的增殖。然而，复合材料中含有不同量的去甲斑蝥素的纳米粒子对骨肉瘤具有不同的抑制作用，对成骨细胞的影响也不同。而且，随着去甲斑蝥素含量的增加，复合材料的抗肿瘤性能得到了增强。总之，本研究开发的 nano-SHAP 系统是一种能够抑制肿瘤生长和诱导成骨细胞增殖的药物输送材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/2fc408f1eb94/BMRI2020-9825073.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/962a0b570088/BMRI2020-9825073.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/8f1de598706c/BMRI2020-9825073.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/027f60dff572/BMRI2020-9825073.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/2e21908e6c51/BMRI2020-9825073.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/e3d17557dddf/BMRI2020-9825073.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/559125b8874e/BMRI2020-9825073.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/2fc408f1eb94/BMRI2020-9825073.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/962a0b570088/BMRI2020-9825073.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/8f1de598706c/BMRI2020-9825073.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/027f60dff572/BMRI2020-9825073.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/2e21908e6c51/BMRI2020-9825073.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/e3d17557dddf/BMRI2020-9825073.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/559125b8874e/BMRI2020-9825073.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6389/7013326/2fc408f1eb94/BMRI2020-9825073.007.jpg

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