Biomaterials in Medicinal Chemistry Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, India.
Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh, 11433, Saudi Arabia.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:875-885. doi: 10.1016/j.msec.2017.05.095. Epub 2017 May 15.
We investigated the use of combined nanoparticles in bone replacement for patients with bone cancer. Bismuth (Bi) is known to have antitumor effects, and the inclusion of Bi in bioactive mineral (M)-substituted hydroxyapatite (M-HAP) may provide anti-cancer properties implant resources. A series of Bi-substituted M-HAP (Bi-M-HAP) nanoparticles with various Bi concentrations was synthesized via the ultrasound irradiation method. The nanoparticles were examined using physicochemical strategies. The cell-substance interface of the nanoparticles was observed in vitro with human osteosarcoma cells and cell multiplication was measured at 1, 3, and 7days of incubation and in vivo in rats after 3weeks of implantation. The nanoparticles promoted osseous proliferation, improved mechanical strength, and repressed the development of cancerous cells. Overall, Bi-M-HAP nanoparticles show promise for treatment of bone cancer and advance the field of embedded biomaterials.
我们研究了联合纳米粒子在骨肿瘤患者骨替代中的应用。已知铋（Bi）具有抗肿瘤作用，将 Bi 纳入生物活性矿物（M）取代的羟基磷灰石（M-HAP）中可能为植入物资源提供抗癌特性。通过超声辐射法合成了一系列具有不同 Bi 浓度的 Bi 取代的 M-HAP（Bi-M-HAP）纳米粒子。通过物理化学策略对纳米粒子进行了检查。用人骨肉瘤细胞在体外观察纳米粒子的细胞物质界面，并在孵育 1、3 和 7 天后以及植入后 3 周的大鼠体内测量细胞增殖。纳米粒子促进了骨质的增殖，提高了机械强度，并抑制了癌细胞的发展。总的来说，Bi-M-HAP 纳米粒子有望用于治疗骨癌，并推动嵌入式生物材料领域的发展。
