Binary functional porous multi mineral-substituted apatite nanoparticles for reducing osteosarcoma colonization and enhancing osteoblast cell proliferation.

We investigated the use of combined nanoparticles in bone replacement for patients with bone cancer. Bismuth (Bi) is known to have antitumor effects, and the inclusion of Bi in bioactive mineral (M)-substituted hydroxyapatite (M-HAP) may provide anti-cancer properties implant resources. A series of Bi-substituted M-HAP (Bi-M-HAP) nanoparticles with various Bi concentrations was synthesized via the ultrasound irradiation method. The nanoparticles were examined using physicochemical strategies. The cell-substance interface of the nanoparticles was observed in vitro with human osteosarcoma cells and cell multiplication was measured at 1, 3, and 7days of incubation and in vivo in rats after 3weeks of implantation. The nanoparticles promoted osseous proliferation, improved mechanical strength, and repressed the development of cancerous cells. Overall, Bi-M-HAP nanoparticles show promise for treatment of bone cancer and advance the field of embedded biomaterials.