通过一锅三组分反应无溶剂合成异吲哚并[2,1-c]吡唑并[1,5-a]喹唑啉和吡唑并[5',1':2,3]嘧啶并[6,1-a]异吲哚衍生物。
Solvent-free synthesis of isoindolo[2,1-c]pyrazolo[1,5-a]quinazoline and pyrazolo[5',1':2,3]pyrimido[6,1-a]isoindol derivatives through a one-pot three-component reaction.
作者信息
Alizadeh-Kouzehrash Meysam, Rahmati Abbas
机构信息
Department of Chemistry, University of Isfahan, P. O. Box 81746-73441, Isfahan, Iran.
出版信息
Mol Divers. 2021 May;25(2):1123-1130. doi: 10.1007/s11030-020-10052-y. Epub 2020 Feb 19.
PMID:32076910
Abstract
Some 5-substituted 3-aminopyrazoles were used for the synthesis of isoindolo[2,1-c]pyrazolo[1,5-a]quinazoline and pyrazolo[5',1':2,3]pyrimido[6,1-a]isoindol derivatives via a mild and efficient one-pot three-component reaction with 2-formylbenzoic acid and different CH-acids under solvent-free condition.
摘要
一些5-取代的3-氨基吡唑通过在无溶剂条件下与2-甲酰基苯甲酸和不同的碳氢酸进行温和且高效的一锅三组分反应，用于合成异吲哚并[2,1-c]吡唑并[1,5-a]喹唑啉和吡唑并[5',1':2,3]嘧啶并[6,1-a]异吲哚衍生物。
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