College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China.
Department of Electrical Engineering and Creative IT Engineering, POSTECH, Pohang, 37673, Republic of Korea.
Angew Chem Int Ed Engl. 2020 May 25;59(22):8630-8634. doi: 10.1002/anie.201916147. Epub 2020 Mar 18.
Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging-guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self-assembly of two water-soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4-PcN4) and consequently enables the fabrication of PcS4-PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4-PcN4. In vivo evaluations suggest that PcS4-PcN4 could not only efficiently visualize a tumor with high contrast through whole-body photoacoustic imaging but also enable excellent photothermal therapy for cancer.
光热诊疗纳米平台在癌症的诊断和影像引导治疗方面具有特别的应用前景。在此，我们通过两个水溶性酞菁衍生物 PcS4 和 PcN4 的直接自组装，开发了一种超分子方法来制备纳米结构的光热诊疗试剂。PcS4 和 PcN4 之间的分子识别特性有助于纳米结构（PcS4-PcN4）的形成，从而能够制备荧光完全猝灭且单重态氧生成减少的 PcS4-PcN4，进而赋予 PcS4-PcN4 高光声和光热活性。体内评估表明，PcS4-PcN4 不仅可以通过全身光声成像高效地对肿瘤进行高对比度可视化，还可以实现出色的癌症光热治疗效果。
