Wu Fengshou, Yue Liangliang, Cheng Kai, Chen Jun, Wong Ka-Leung, Wong Wai-Kwok, Zhu Xunjin
Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430072, People's Republic of China.
Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China.
ACS Biomater Sci Eng. 2020 Sep 14;6(9):5230-5239. doi: 10.1021/acsbiomaterials.0c00684. Epub 2020 Aug 31.
The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively.
在过去十年中，用于个性化多功能光热诊疗的近红外（NIR）吸收纳米剂的开发引起了相当大的关注。最近，具有良好生物安全性的有机纳米材料被认为是有前景的光热诊疗剂，但其简便合成仍然具有挑战性。受碳纳米点制备的启发，我们采用一种简便方法制备用于多功能光热诊疗的近红外吸收酞菁基纳米点（ZnPc-NDs）。酞菁在纳米点中的显著聚集导致荧光完全猝灭，这提供了高光热转换效率（η = 45.7%）。ZnPc-NDs在水介质中分散良好，平均直径约为80 nm。在ZnPc-NDs表面进一步共轭生物素可得到肿瘤靶向酞菁纳米点（ZnPc-BT）。ZnPc-BT具有良好的生物相容性、强烈的光声信号、高肿瘤蓄积性，并在体内具有有效的肿瘤抑制作用。本文为进一步开发具有成像和治疗功能的纳米药物以精确有效地治疗癌症提供了新的见解。
