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使用猫科动物浓缩红细胞对一只患有自发性血腹症的家养雪貂成功进行异种输血。

Successful xenotransfusion in a domestic ferret with spontaneous hemoperitoneum using feline packed red blood cells.

作者信息

Bell Amy L, Gladden Jay N, Graham Jennifer E

机构信息

Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.

出版信息

J Vet Emerg Crit Care (San Antonio). 2020 May;30(3):336-341. doi: 10.1111/vec.12943. Epub 2020 Feb 20.

DOI:10.1111/vec.12943
PMID:32077204
Abstract

OBJECTIVE

To describe the diagnosis, management, and outcome of a ferret with spontaneous hemoperitoneum with surgical intervention and xenotransfusion of type A feline packed red blood cells (pRBCs).

CASE SUMMARY

A domestic ferret diagnosed with a spontaneous hemoperitoneum secondary to a hepatic mass received isotonic crystalloids, hypertonic saline, and an allogenic blood transfusion perioperatively. Postoperatively, the ferret developed progressive anemia and tachycardia refractory to fluid therapy and, given a lack of additional allogenic blood sources, received a xenotransfusion of feline pRBCs. The ferret was hospitalized for 4 days postoperatively and developed a presumed delayed transfusion reaction characterized by transient hyperbilirubinemia. At a 6-month recheck, the ferret was doing well clinically.

NEW OR UNIQUE INFORMATION PROVIDED

This is the first reported case of successful xenotransfusion of feline pRBCs in a ferret. Although xenotransfusion of ferrets with feline blood products is not recommended as a routine procedure, it remains a viable option in critical situations in which ferret blood is unavailable.

摘要

目的

描述一只患有自发性腹腔积血的雪貂在接受手术干预和输注A型猫浓缩红细胞(pRBCs)进行异种输血后的诊断、治疗及预后情况。

病例摘要

一只因肝脏肿块继发自发性腹腔积血的家养雪貂在围手术期接受了等渗晶体液、高渗盐水和同种异体输血。术后,这只雪貂出现进行性贫血和对液体治疗无效的心动过速,由于缺乏额外的同种异体血源,接受了猫pRBCs的异种输血。术后这只雪貂住院4天,出现了以短暂性高胆红素血症为特征的推测性延迟输血反应。在6个月的复查时,这只雪貂临床状况良好。

提供的新的或独特信息

这是首次报道在雪貂中成功进行猫pRBCs异种输血的病例。虽然不建议将雪貂与猫血液制品的异种输血作为常规操作,但在无法获得雪貂血液的危急情况下,它仍然是一个可行的选择。

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引用本文的文献

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Xenotransfusion of Blood from Dog to Cat: Should Canine Blood Be Our First Choice for Feline Transfusion in Emergency Situations?从狗到猫的异种输血:在紧急情况下,犬血应成为猫输血的首选吗?
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Preliminary Investigation of Bovine Whole Blood Xenotransfusion as a Therapeutic Modality for the Treatment of Anemia in Goats.牛全血异种输血作为治疗山羊贫血的一种治疗方式的初步研究。
Front Vet Sci. 2021 Mar 4;8:637988. doi: 10.3389/fvets.2021.637988. eCollection 2021.