Am J Epidemiol. 2020 Sep 1;189(9):873-884. doi: 10.1093/aje/kwaa023.
Microvascular dysfunction (MVD) is a common pathophysiological change that occurs in various diseases, such as type 2 diabetes mellitus (T2DM), heart failure, dementia, and depression. Recent technical advances have enabled noninvasive measurement and quantification of microvascular changes in humans. In this paper, we describe the protocols of the microvascular measurements applied in the Maastricht Study, an ongoing prospective, population-based cohort study of persons aged 40-75 years being carried out in the southern part of the Netherlands (baseline data assessment, November 2010-January 2020). The study includes a variety of noninvasive measurements in skin, retina, brain, and sublingual tissue, as well as plasma and urine biomarker assessments. Following this, we summarize our main findings involving these microvascular measurements through the end of 2018. Finally, we provide a brief perspective on future microvascular investigations within the framework of the Maastricht Study.
微血管功能障碍（MVD）是一种常见的病理生理变化，发生在多种疾病中，如 2 型糖尿病（T2DM）、心力衰竭、痴呆和抑郁症。最近的技术进步使得能够无创测量和量化人类微血管的变化。在本文中，我们描述了微血管测量在马斯特里赫特研究中的应用方案，该研究是一项正在进行的前瞻性、基于人群的队列研究，在荷兰南部进行，研究对象为 40-75 岁的人群（基线数据评估，2010 年 11 月至 2020 年 1 月）。该研究包括皮肤、视网膜、大脑和舌下组织的各种无创测量，以及血浆和尿液生物标志物评估。接下来，我们总结了我们通过 2018 年底的这些微血管测量的主要发现。最后，我们简要介绍了在马斯特里赫特研究框架内进行未来微血管研究的前景。
